CC BY-NC-ND 4.0 · Journal of Gastrointestinal and Abdominal Radiology 2023; 06(01): 042-046
DOI: 10.1055/s-0042-1753535
Case Report

Multicentric Fibrolamellar Hepatocellular Carcinoma: A Rare Case Report

Mayank Goyal
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Komerisetty Rozaih
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
Swapnil Sheth
1   Department of Radiology, Sir Ganga Ram Hospital, New Delhi, India
,
2   Department of CT and MRI, Sir Ganga Ram Hospital, New Delhi, India
,
Tarvinder B. S. Buxi
2   Department of CT and MRI, Sir Ganga Ram Hospital, New Delhi, India
› Author Affiliations

Abstract

Multicentric fibrolamellar hepatocellular carcinoma has not been reported yet in the world as of our knowledge. A Medline search for the term “multicentric fibrolamellar HCC” did not return any results. To our knowledge, this is the first case report of multi-centric fibrolamellar hepatocellular carcinoma (HCC). We present the case of a 22-year-old male patient who had complaints of epigastric pain for 1 month. His general physical examinations were normal. Computed tomography of the abdomen revealed multiple hyper-enhancing space-occupying lesions, one of which showed a central scar. The final diagnosis of the case was multicentric fibrolamellar HCC, which was biopsy proven.



Publication History

Article published online:
15 August 2022

© 2022. Indian Society of Gastrointestinal and Abdominal Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Craig JR, Peters RL, Edmondson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer 1980; 46 (02) 372-379
  • 2 Vivekanandan P, Micchelli ST, Torbenson M. Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. Hum Pathol 2009; 40 (03) 293-299
  • 3 Ichikawa T, Federle MP, Grazioli L, Madariaga J, Nalesnik M, Marsh W. Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology 1999; 213 (02) 352-361
  • 4 Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood. AMA J Dis Child 1956; 91 (02) 168-186
  • 5 Torbenson M. Review of the clinicopathologic features of fibrolamellar carcinoma. Adv Anat Pathol 2007; 14 (03) 217-223
  • 6 Saab S, Yao F. Fibrolamellar hepatocellular carcinoma. Case reports and a review of the literature. Dig Dis Sci 1996; 41 (10) 1981-1985
  • 7 McLarney JK, Rucker PT, Bender GN, Goodman ZD, Kashitani N, Ros PR. Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics 1999; 19 (02) 453-471
  • 8 Friedman AC, Lichtenstein JE, Goodman Z, Fishman EK, Siegelman SS, Dachman AH. Fibrolamellar hepatocellular carcinoma. Radiology 1985; 157 (03) 583-587
  • 9 Brandt DJ, Johnson CD, Stephens DH, Weiland LH. Imaging of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol 1988; 151 (02) 295-299
  • 10 Quillin SP, Atilla S, Brown JJ, Borrello JA, Yu CY, Pilgram TK. Characterization of focal hepatic masses by dynamic contrast-enhanced MR imaging: findings in 311 lesions. Magn Reson Imaging 1997; 15 (03) 275-285
  • 11 Oliver III JH, Baron RL. Helical biphasic contrast-enhanced CT of the liver: technique, indications, interpretation, and pitfalls. Radiology 1996; 201 (01) 1-14
  • 12 Vilgrain V, Fléjou JF, Arrivé L. et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 1992; 184 (03) 699-703
  • 13 Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A. Hepatic adenomas: imaging and pathologic findings. Radiographics 2001; 21 (04) 877-892 , discussion 892–894
  • 14 Winston CB, Schwartz LH, Fong Y, Blumgart LH, Panicek DM. Hepatocellular carcinoma: MR imaging findings in cirrhotic livers and noncirrhotic livers. Radiology 1999; 210 (01) 75-79
  • 15 Shriki JE, Seyal AR, Dighe MK. et al. CT of atypical and uncommon presentations of hepatocellular carcinoma. Am J Roentgenol 2015; 205 (04) W411-23