CC BY 4.0 · Pharmaceutical Fronts 2022; 04(02): e43-e60
DOI: 10.1055/s-0042-1751036
Review Article

Lipid-Based Nanocarrier Systems for Drug Delivery: Advances and Applications

Yan-Qi Zhao
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
2   University of Chinese Academy of Sciences, Beijing, People's Republic of China
,
Li-Jun Li
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
2   University of Chinese Academy of Sciences, Beijing, People's Republic of China
,
Er-Fen Zhou
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
3   School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China
,
Jiang-Yue Wang
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
4   School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China
,
Ying Wang
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
2   University of Chinese Academy of Sciences, Beijing, People's Republic of China
,
Lin-Miao Guo
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
2   University of Chinese Academy of Sciences, Beijing, People's Republic of China
,
Xin-Xin Zhang
1   State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China
2   University of Chinese Academy of Sciences, Beijing, People's Republic of China
› Author Affiliations
Funding We acknowledge the financial support of the Chinese Pharmacopoeia Commission (Grant No. 2021Y19), the National Natural Science Foundation of China (Grant No. 81973250), and the Natural Science Foundation of Shanghai (Grant No. 21ZR1475800).


Abstract

Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based nanocarriers such as insufficient targeting, capture by the reticuloendothelial system, and fast elimination limit the efficiency of drug delivery and therapeutic efficacy. Therefore, a series of multifunctional lipid-based nanocarriers have been developed to enhance the accumulation of drugs in the lesion site, aiming for improved diagnosis and treatment of various diseases. In this review, we summarized the advances and applications of lipid-based nanocarriers from traditional to novel functional lipid preparations, including liposomes, stimuli-responsive lipid-based nanocarriers, ionizable lipid nanoparticles, lipid hybrid nanocarriers, as well as biomembrane-camouflaged nanoparticles, and further discussed the challenges and prospects of this system. This exploration may give a complete idea viewing the lipid-based nanocarriers as a promising choice for drug delivery system, and fuel the advancement of pharmaceutical products by materials innovation and nanotechnology.



Publication History

Received: 31 March 2022

Accepted: 18 May 2022

Article published online:
04 July 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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