CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol
DOI: 10.1055/s-0042-1750764
Systematic Review

Marginal versus Segmental Mandibulectomy in the Treatment of Oral Cavity Cancer: A Systematic Review and Meta-analysis

1   Department of Otorhinolaryngology - Head and Neck Surgery, Hospital Universitario de Donostia, San Sebastian, Guipuzcoa, Spain
Miguel Mayo-Yanez
2   Department of ENT, Hospital Juan Canalejo de La Coruña, A Coruna, Galicia, Spain
Giuditta Manelli
3   Department of ENT, Azienda Ospedaliero Universitaria Careggi, Firenze, Toscana, Italy
Gabriele Molteni
4   Department of ENT, Università degli Studi di Verona, Verona, Veneto, Italy
Jerome Lechien
5   Department of ENT, Hôpital Foch, Suresnes, Île-de-France, France
Nicolas Fakhry
6   Department of ENT, Assistance Publique Hôpitaux de Marseille, Marseille, Provence-Alpes-Côte d'Azu, France
Antoine Melkane
7   Department of ENT, Hôpital Hôtel Dieu de France, Beirut, Lebanon
Christian Calvo-Henriquez
8   Department of ENT, Hospital Universitario de Santiago de Compostela, Santiago de Compostela, Galicia, Spain
David Kalfert
9   Department of ENT, Charles University, Praha, Czech Republic
Tareck Ayad
10   Department of ENT, University of Montreal Hospital Centre, Montreal, Quebec, Canada
› Author Affiliations


Introduction Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy in the oral cavity. Two types of mandibular resections have been described: the segmental mandibulectomy and the marginal mandibulectomy. Both may have a different impact over the quality of life, oncological prognosis, and functional or aesthetic result.

Objectives The aim of this study was to systematically explore the literature to determine the survival outcomes and disease control rates in patients who underwent segmental or marginal mandibulectomy for OCSCC with histological evidence of cortical and medullary bone invasion.

Data Synthesis This review involved a systematic search of the electronic databases MEDLINE/PUBMED, Google Scholar, Ovid Medline, Embase, and Scopus including articles from 1985 to 2019. Fifteen articles were included for qualitative analysis and 11 articles were considered for meta-analysis calculations. All of them correspond to retrospective cohort studies.

Conclusion This systematic review reveals the low-level evidence regarding the impact over local control or survival according to the type of mandibulectomy. Our results need to be considered with precaution according to the limited evidence available. We just found difference regarding the 5-year disease-free survival, and a tendency in favor of segmental mandibulectomy was confirmed when medullary invasion was evident.

Supplementary Material

Publication History

Received: 24 February 2022

Accepted: 15 May 2022

Article published online:
11 April 2023

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