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CC BY-NC-ND 4.0 · World J Nucl Med 2022; 21(04): 320-324
DOI: 10.1055/s-0042-1750405
Case Report

Delivery of Radioiodine Ablation in a Patient with End-Stage Renal Disease

Andrew T. Bussey
1   Department of Nuclear Medicine, South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom
,
Aung Tin
2   The James Cook Cancer Institute, South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom
,
Neil Hoye
3   Department of Renal Medicine, South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom
,
Mark Richardson
1   Department of Nuclear Medicine, South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom
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Abstract

This case presents a pragmatic approach to the management of a radioiodine remnant ablation patient on hemodialysis which required no pretherapeutic dosimetric measurements. Pretreatment radiation dose modeling was performed using literature values for radioiodine hemodialysis extraction efficacies to determine a safe treatment regimen including adjustment of the administered activity and hemodialysis frequency. The pretreatment modeling was subsequently verified using external and blood radiation monitoring during treatment.

Keywords

thyroid carcinoma - I-131 - hemodialysis - end-stage renal disease


Publication History

Article published online:
02 September 2022

© 2022. World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Lassmann M, Hänscheid H, Chiesa C, Hindorf C, Flux G, Luster M. EANM Dosimetry Committee. EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy. Eur J Nucl Med Mol Imaging 2008; 35 (07) 1405-1412
    CrossrefPubMedSearch in Google Scholar
  • 2 Bussey A, Richardson M, Baker A. External dose-rate modelling of RRA radioiodine patients. Nucl Med Commun 2019;40(4):393–453
  • 3 Vermandel M, Debruyne P, Beron A. et al. Management of patients with renal failure undergoing dialysis during 131I therapy for thyroid cancer. J Nucl Med 2020; 61 (08) 1161-1170
    CrossrefPubMedSearch in Google Scholar
  • 4 Owen Jr WF, Lew NL, Liu Y, Lowrie EG, Lazarus JM. The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 1993; 329 (14) 1001-1006
    CrossrefPubMedSearch in Google Scholar
  • 5 Held PJ, Port FK, Wolfe RA. et al. The dose of hemodialysis and patient mortality. Kidney Int 1996; 50 (02) 550-556
    CrossrefPubMedSearch in Google Scholar
  • 6 Lowrie EG, Laird NM, Parker TF, Sargent JA. Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study. N Engl J Med 1981; 305 (20) 1176-1181
    CrossrefPubMedSearch in Google Scholar
  • 7 Depner TA. Daily hemodialysis efficiency: an analysis of solute kinetics. Adv Ren Replace Ther 2001; 8 (04) 227-235
    CrossrefPubMedSearch in Google Scholar
  • 8 Suri RS, Nesrallah GE, Mainra R. et al. Daily hemodialysis: a systematic review. Clin J Am Soc Nephrol 2006; 1 (01) 33-42
    CrossrefPubMedSearch in Google Scholar
  • 9 Piruzan E, Haghighatafshar M, Faghihi R, Entezarmahdi SM. Calculation of blood dose in patients treated with 131I using MIRD, imaging, and blood sampling methods. Medicine (Baltimore) 2016; 95 (11) e3154
    CrossrefPubMedSearch in Google Scholar
  • 10 Loevinger R, Budinger TF, Watson EE. 1988. MIRD Primer for Absorbed Dose Calculations. New York, NY: Society of Nuclear Medicine;
    Search in Google Scholar