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CC BY-NC-ND 4.0 · World J Nucl Med 2022; 21(02): 142-147
DOI: 10.1055/s-0042-1750336
Original Article

Planar 99mTc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report

A.T. Orunmuyi
1   Department of Nuclear Medicine, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria
,
A.A. Oladeji
2   Radiation Oncology Department, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria
,
E.U. Azodoh
3   Chivar Clinics and Urology Centre, FCT Abuja, Nigeria
,
O.A. Omisanjo
4   Department of Surgery, Urology Division, Lagos State University College of Medicine and Lagos State University Teaching Hospital, Ikeja, Nigeria
,
E.O. Olapade-Olaopa
5   Department of Surgery, Urology Division, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria
› Author Affiliations
Funding None.
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Abstract

Objective Technetium-99m labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography/computed tomography (SPECT/CT) is a suitable alternative to prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging. However, the availability of SPECT/CT in many developing countries is limited.

Materials and Methods To evaluate the utility of planar 99mTc-PSMA in the absence of SPECT/CT, we compared planar 99mTc-PSMA and routine bone scan imaging in low-, intermediate-, and high-risk prostate cancer in five patients with histologically confirmed prostate cancer who had both scans within a period of less than 4 days. The mean age of patients was 66.8 ± 5.24, and the median prostate-specific antigen level was 175 ng/mL (range: 0–778 ng/mL).

Results Planar 99mTc-PSMA scan provided no additional benefit over bone scans in the low-risk prostate cancer cases. In the cases with intermediate-risk prostate cancers, planar 99mTc-PSMA indicated complete and partial response to treatment in oligometastatic and widespread metastatic disease, respectively. In one patient with high-risk prostate cancer, planar 99mTc-PSMA detected additional skeletal lesions that were not seen on bone scan.

Conclusion In the absence of SPECT/CT, planar 99mTc-PSMA was useful for confirming extent of disease in treated intermediate- and high-risk prostate cancer. It showed little value in low-risk prostate cancer, especially when bone scan is normal. It was particularly useful for treatment response assessment in oligometastatic disease, and its utility should be further explored.

Keywords

planar 99mTc HYNIC PSMA - bone scan - equivocal scans - SPECT

Authors' Contribution

OAT was involved in conceptualization, design, definition of intellectual content, clinical studies, data acquisition, data analysis, statistical analysis, manuscript preparation, and manuscript review. AAO was involved in literature search, clinical studies, data acquisition, data analysis, manuscript editing, and review. EUA was involved in literature search, clinical studies, data acquisition, manuscript editing, and review. OAO was involved in designing, clinical studies, data acquisition, data analysis, manuscript preparation, and review. EOO was involved in designing, clinical studies, data acquisition, manuscript preparation, editing, and review. OAT has provided guarantee.


Sources of Support

None.




Publication History

Article published online:
28 June 2022

© 2022. World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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