Download PDF
CC BY 4.0 · Chinese medicine and natural products 2022; 02(02): e96-e106
DOI: 10.1055/s-0042-1750324
Original Article

Status of Clinical Application of Yufeng Ningxin Preparations and the Meta-Analysis of Its Efficacy and Safety in the Treatment of Cardiovascular and Cerebrovascular Diseases

Lishuang Zhang
1   Internal Medicine-Cardiovascular Department, The Fourth Affiliated Hospital of Tianjin University of Traditional Chinese Medicine and Tianjin Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, China
,
Yaxia Ma
1   Internal Medicine-Cardiovascular Department, The Fourth Affiliated Hospital of Tianjin University of Traditional Chinese Medicine and Tianjin Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, China
,
Ying Wang
2   Jinrun Pharmaceutical Co., Ltd Tianjin, China
,
Feng Jiang
3   Institute of International Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
› Author Affiliations Funding This work was supported by Tianjin Municipal Education Commission Scientific Research Program (2021KJ170).
› Further Information
   Permissions and Reprints

Abstract

Objective The objective of this study was to analyze the status of the clinical application of Yufeng Ningxin (YFNX) preparations and systematically evaluate their efficacy and safety in the treatment of cardiovascular and cerebrovascular diseases.

Methods Through searching databases of China National Knowledge Infrastructure, Wanfang, SinoMed, VIP, PubMed, Embase, and the Cochrane Library, the literature of clinical research on YFNX preparations in treating malignant tumors of cardiovascular and cerebrovascular diseases from the establishment of the databases to February 2021 was collected. The clinical randomized controlled trials and case–control studies of cardiovascular and cerebrovascular diseases treated with these preparations were analyzed. Two reviewers independently screened literature, extracted data, and assessed the risk of bias in the included studies, and meta-analysis was performed by using ReMan 5.3 software to analyze the efficacy and safety of YFNX preparations in the treatment of cardiovascular and cerebrovascular diseases.

Results A total of 29 clinical studies were finally included. The dosage forms were dropping pills, tablets, capsules, and granules. The preparations were used for the treatment of coronary heart disease, hypertension, neuropathic headache, etc. This study systematically evaluated the efficacy and safety of YFNX preparations in the treatment of coronary heart disease, hypertension, and nervous headache. A total of 1,162 cases were included in 13 studies, 582 cases of the YFNX preparation group and 580 cases of the Western medicine group. The results of meta-analysis showed that the clinical efficacy of YFNX preparations combined with the Western medicine group in the treatment of coronary heart disease and hypertension, improving electrocardiogram and reducing the frequency and duration of angina attacks, was better than that of the simple Western medicine group, and the difference was statistically significant.

Conclusion YFNX preparations are effective for coronary heart disease, hypertension, and neuropathic headache, and the adverse reactions are few.

Keywords

Yufeng Ningxin preparations - cardiovascular and cerebrovascular diseases - clinical randomized controlled trials - case–control study - meta-analysis

Credit Authorship Contribution Statement

Lishuang Zhang: Data curation, visualization, software, formal analysis, and writing–original draft. Yaxia Ma: Data curation, formal analysis, and software. Ying Wang: Formal analysis, and writing—original draft. Feng Jiang: Conceptualization, methodology, funding acquisition, and writing–review & editing.




Publication History

Received: 11 January 2022

Accepted: 03 March 2022

Article published online:
22 August 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Liu YM, Chen Q, Wu FF. et al. Modern research progress of Pueraria isoflavone. Fujian Tea 2020; 42 (01) 18-19
    Google Scholar
  • 2 Luo C, Bu SZ, Wang FY. Pharmacological mechanism and clinical progress in the treatment of type 2 diabetes with Puerarin. Basic Clin Med 2016; 36 (11) 1582-1585
    Google Scholar
  • 3 Writing Group of the Chinese Cardiovascular Health and Disease Report. Outline of Chinese cardiovascular health and disease report 2019. Prev Treat Cardio Cerebrovasc Dis 2020; 20 (05) 437-450
    Google Scholar
  • 4 Ye H, He MH. Clinical observation of Yufeng Ningxin dropping pills in the treatment of hypertension of yin deficiency and yang hyperactivity syndrome. Chin Tradit Herbal Drugs 2003; 34 (09) 840-841
    Google Scholar
  • 5 Yan ZQ, Jiao QH, He XP. Clinical effect of Yufeng Ningxin dropping pills in the treatment of angina with heart blood stasis. Chin J Integr Med Cardio Cerebrovasc Dis 2020; 18 (20) 3333-3335
    Google Scholar
  • 6 Cheng HC. Research on the clinical effects of Yufeng Ningxin dropping pills on hypertension companied with headache. Woman's Day 2019; (04) 45
    Google Scholar
  • 7 Yang SY. Yufeng ningxin dripping pills treated angina pectoris for 45 cases. Guangming J Chin Med 2019; 34 (03) 413-414
    Google Scholar
  • 8 Cheng H, Jia XB. Clinical study on Yufeng Ningxin tablets combined with nifedipine in treatment of chronic stable angina pectoris. Drugs Clin 2019; 34 (11) 3255-3259
    Google Scholar
  • 9 Sun Y. Clinical observation of Yufeng Ningxin dropping pills in the treatment of neuropathic headache. Guide China Med 2019; 17 (29) 178
    Google Scholar
  • 10 Chen J, Wang SM. Clinical study of Yufeng Ningxin dripping pills combined with trimetazidine in treatment of coronary heart disease. Drugs Clin 2018; 33 (06) 1371-1375
    Google Scholar
  • 11 Zheng SL, Xiao Y. Eighty cases of coronary heart disease treated with Yufeng Ningxin dropping pills combined with Western medicine. Guangxi Zhongyiyao 2017; 40 (06) 26-27
    Google Scholar
  • 12 Yan W. Observation of Yufeng Ningxin dropping pills combined with flunarizine for the treatment of migraine. Home Med 2017; (09) 140
    Google Scholar
  • 13 An LJ. Clinical observation of Yufeng Ningxin dropping pills in the treatment of neuropathic headache. Nei Mongol J Tradit Chin Med 2017; 36 (04) 10
    Google Scholar
  • 14 Dou LG. The effect observation of Yufeng Ningxin balls in the treatment of neuropathic headache. China Heal Stand Manag 2016; 7 (23) 129-130
    Google Scholar
  • 15 Peng XW. Clinical observation of compound Danshen injection combined with Yufeng Ningxin capsules for the treatment of transient ischemic attack. Hubei J Tradit Chin Med 2015; 37 (04) 51
    Google Scholar
  • 16 He CF. Forty-two cases with hypertension companied with headache treated with Yufeng Ningxin tablets. Heal 2014; 8 (10) 152
    Google Scholar
  • 17 Liang LH, Tang XM, Xie G. Clinical observation of Yufeng Ningxin dropping pills in the treatment of angina. Zhonghua Linchuang Yishi Zazhi 2014; 42 (12) 51-52
    Google Scholar
  • 18 Fu QW. Clinical research on treating nervous headache with Yufeng Ningxin pills. Clin J Chin Med 2014; 6 (04) 119-120
    Google Scholar
  • 19 Guo Z, Sheng G, Wen LN. et al. Seventy-two cases with dizziness treated by Yufeng Ningxin dropping pills combined with treatment of Yongquan (KI 1) on both feet. Shaanxi J Tradit Chin Med 2014; 35 (09) 1161-1162
    Google Scholar
  • 20 Xing GY, Deng ZX, Zhang XH. Clinical observation on effect of moricizine and Yufeng Ningxin tablets in treatment of ventricular premature in elderly patients with coronary heart disease. J Clin Exp Med 2013; 12 (17) 1402-1403 , 1405
    Google Scholar
  • 21 Liang LH, Xie G, Jing Y. et al. Sixty cases with coronary heart disease treated with Yufeng Ningxin dropping pills. Mod J Integr Tradit Chin West Med 2011; 20 (22) 2860
    Google Scholar
  • 22 Shi HW. Analysis of 150 cases of neuropathic headache treated with nimodipine combined with Yufeng Ningxin tablets. Chin J Pract Nerv Dis 2011; 14 (11) 86-87
    Google Scholar
  • 23 Yang YL, Tang YQ, Jiang WD. Fifty cases with dizziness due to vertebrobasilar insufficiency treated by Yufeng Ningxin tablets combined with Yinxing Damo injection. Zhejiang J Tradit Chin Med 2010; 45 (09) 700
    Google Scholar
  • 24 Feng YM. Clinical observation of vertebrobasilar insufficiency vertigo transcranial Doppler treated by massage. Asia Pac Tradit Med 2007; 3 (04) 49-50
    Google Scholar
  • 25 Zhang F, Yang ZX, Lai HA. Eighty-four cases of neuropathic headache treated with Yufeng Ningxin tablets. Shaanxi J Tradit Chin Med 2006; 27 (04) 448-449
    Google Scholar
  • 26 Zhu JG, Lian FM, Tian L. et al. Clinical trial of Yufeng Ningxin drop pills for nervous headache. Zhongyao Xinyao Yu Linchuang Yaoli 2004; 15 (03) 206-207 , 218
    Google Scholar
  • 27 Sun XG. Clinical observation of Yufeng Ningxin tablets for the treatment of angina pectoris in coronary heart disease. J Shaanxi Coll Tradit Chin Med 2003; 26 (04) 16
    Google Scholar
  • 28 Zheng FF. Observation of the effects of Tongxinluo capsules combined with Yufeng Ningxin tablets for the treatment of cerebral angiospasm. Prop Diagn Treat Skills 2003; (04) 1-2
    Google Scholar
  • 29 Liu YD, Shi YH, Li JT. Fifty-eight cases with senile myocardial ischemia treated with Yufeng Ningxin tablets J. Zhong Yi Xue 2003; 44 (02) 126
    Google Scholar
  • 30 Gu Z. Observation of the efficacy of Yufeng Ningxin granules for the treatment of sudden deafness. Shandong J Tradit Chin Medcine 2001; 20 (10) 599-600
    Google Scholar
  • 31 Wang CP, Guo WX, Su WG. et al. A clinical observation of Yufeng Ningxin granule for angina pectoris. Zhongyao Xinyao Yu Linchuang Yaoli 1999; 10 (03) 141-143
    Google Scholar
  • 32 Ling ZP, Li YC. Clinical observation of the effect of oral administration of amiodarone combined with Yufeng Ningxin tablets on the treatment of chronic arrhythmia. J Med Theory Pract 1988; 1 (03) 17-18
    Google Scholar
  • 33 Guo S, Zhou CZ. The difference and similarity of promoting blood circulation and removing blood stasis in the treatment of acute and chronic cardio-cerebrovascular diseases. China Med Her 2020; 17 (19) 140-143
    Google Scholar
  • 34 Liang YP. Observation of the application effect of medicines with effects of activating blood flow and resolving blood stasis in the treatment of cardiovascular and cerebrovascular diseases. J Clin Med Lit 2018; 5 (52) 174-175
    Google Scholar