CC BY-NC-ND 4.0 · J Neuroanaesth Crit Care 2022; 09(02): 106-111
DOI: 10.1055/s-0042-1750093
Original Article

Retrospective Analysis of 1998 Patients Diagnosed with Brain Death between 2011 and 2019 in Turkey

1   Department of Intensive Care Unit, Kayseri City Training and Research Hospital, Kayseri, Turkey
,
Gulseren Elay
2   Department of Intensive Care Unit, Gaziantep University, Gaziantep, Turkey
,
3   Adana Organ Transplantation Regional Coordination Center, Adana, Turkey
,
Ilhan Bahar
4   Department of Intensive Care Unit, Katip Çelebi Research Hospital, İzmir, Turkey
› Author Affiliations

Abstract

Background Organ transplantation reduces mortality and morbidity in patients with end-stage organ failure. The number of living organ donations is not enough to meet the current organ transplantation need; therefore, there is an urgent need for organ donation from cadavers. We aimed to determine the organ donation rates and reveal the obstacles against donation.

Methods This study is designed as a retrospective multicenter study consisting of eight university hospitals, three training and research hospitals, 26 state hospitals, and 74 private hospitals in nine provinces in Turkey. A total of 1,998 patients diagnosed with brain death between January 2011 to April 2019 were examined through the electronic medical records data system.

Results Median patient age was 38 (IQR: 19–57), and 1,275 (63.8%) patients were male. The median time between the intensive care unit admission and brain death diagnosis was 56 (IQR:2–131) hours. The most commonly used confirmatory diagnostic test was computed tomography in 216 (30.8%) patients, and the most common cause of brain death was intraparenchymal hemorrhage with 617 (30.9%) patients. A total of 1,646 (82.4%) families refused to permit organ donation. The most common reasons for refusal were family disagreement (68%), social/relative pressure (24%), and religious beliefs (8%).

Conclusions Many families refuse permission for organ donation; some of the provinces included in this study experienced years of exceptionally high refusal rates.



Publication History

Article published online:
20 July 2022

© 2022. Indian Society of Neuroanaesthesiology and Critical Care. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Kumar L. Brain death and care of the organ donor. J Anaesthesiol Clin Pharmacol 2016; 32 (02) 146-152
  • 2 Turkish Neurological Society. Diagnostic guidelines for brain death. Turk J Neurol 2014; 20 (03) 101-104
  • 3 Ding ZY, Zhang Q, Wu JW, Yang ZH, Zhao XQ. A comparison of brain death criteria between China and the United States. Chin Med J (Engl) 2015; 128 (21) 2896-2901
  • 4 Pandey A, Sahota P, Nattanmai P, Newey CR. Variability in diagnosing brain death at an Cademic Medical Center. Neurosci J 2017; 2017: 6017958
  • 5 Greer DM, Varelas PN, Haque S, Wijdicks EF. Variability of brain death determination guidelines in leading US neurologic institutions. Neurology 2008; 70 (04) 284-289
  • 6 Goodarzi P, Aghayan HR, Larijani B. et al. Tissue and organ donation and transplantation in Iran. Cell Tissue Bank 2015; 16 (02) 295-301
  • 7 Girlanda R. Deceased organ donation for transplantation: challenges and opportunities. World J Transplant 2016; 6 (03) 451-459
  • 8 Oegan ve doku nakli hizmetleri yönetmeliği, Resmî Gazete Tarihi: 01.02. 2012 Resmî Gazete Sayısı: 28191. Available at: MevzuatNo=15860&MevzuatTur=7&MevzuatTertip=5">https://www.mevzuat.gov.tr/mevzuatMevzuatNo=15860&MevzuatTur=7&MevzuatTertip=5">MevzuatNo=15860&MevzuatTur=7&MevzuatTertip=5
  • 9 Wahlster S, Wijdicks EF, Patel PV. et al. Brain death declaration: practices and perceptions worldwide. Neurology 2015; 84 (18) 1870-1879
  • 10 Wijdicks EFM, Varelas PN, Gronseth GS. et al. Evidence-based guideline update: determining brain death in adults. 2010; 74: 1911-1918
  • 11 Domínguez-Gil B, Matesanz R. International figures on donation and transplantation. Documents produced by the council of Europe European Committee (Partial Agreement) on organ Transplantation (CD-P-TO). Year 2016; 2017
  • 12 Can F, Hovardaoglu S. Organ donation: a comparison of donating and nondonating families in Turkey. Transplant Proc 2017; 49 (09) 1969-1974
  • 13 Ramadurg UY, Gupta A. Impact of an educational intervention on increasing the knowledge and changing the attitude and beliefs towards organ donation among medical students. J Clin Diagn Res 2014; 8 (05) JC05-JC07
  • 14 Spigner C, Weaver M, Cárdenas V, Allen MD. Organ donation and transplantation: ethnic differences in knowledge and opinions among urban high school students. Ethn Health 2002; 7 (02) 87-101
  • 15 Bilgel H, Sadikoglu G, Goktas O, Bilgel N. A survey of the public attitudes towards organ donation in a Turkish community and of the changes that have taken place in the last 12 years. Transpl Int 2004; 17 (03) 126-130
  • 16 Daly BJ. End-of-life decision making, organ donation, and critical care nurses. Crit Care Nurse 2006; 26 (02) 78-86
  • 17 Sarıtaş A, Acar Çinleti B, Zincircioğlu Ç, Uzun U, Köse I, Şenoğlu N. Brain death in intensive care units: problems, differences in methods of diagnosis, and donor care. Exp Clin Transplant. 2018 DOI: 10.6002/ect.2017.0293
  • 18 Mercado-Martínez FJ, Padilla-Altamira C, Díaz-Medina B. et al. Views of Health Care Personnel on Organ Donation and Transplantation: A Literature Review. Texto Context—Enferm. 2015
  • 19 Demir T, Selimen D, Yildirim M, Kucuk HF. Knowledge and attitudes toward organ/tissue donation and transplantation among health care professionals working in organ transplantation or dialysis units. Transplant Proc 2011; 43 (05) 1425-1428
  • 20 Pelletier ML. The needs of family members of organ and tissue donors. Hear Lung 1993; 22 (02) 151-157
  • 21 DeJong W, Franz HG, Wolfe SM. et al. Requesting organ donation: an interview study of donor and nondonor families. Am J Crit Care 1998; 7 (01) 13-23
  • 22 Ríos A, Ramírez P, Galindo PJ. et al. Primary health care personnel faced with cadaveric organ donation: a multicenter study in south-eastern Spain. Clin Transplant 2008; 22 (05) 657-663
  • 23 Topbaş M, Can G, Can MA, Ozgün S. Outmoded attitudes toward organ donation among Turkish health care professionals. Transplant Proc 2005; 37 (05) 1998-2000
  • 24 Saleem T, Ishaque S, Habib N. et al. Knowledge, attitudes and practices survey on organ donation among a selected adult population of Pakistan. BMC Med Ethics 2009; 10: 5
  • 25 Escudero D, Valentín MO, Escalante JL. et al. Intensive care practices in brain death diagnosis and organ donation. Anaesthesia 2015; 70 (10) 1130-1139
  • 26 Türkmen E, Sevinç S, İlhan M. Intensive care units in Turkish hospitals: do they meet the minimum standards?. Nurs Crit Care 2016; 21 (05) e1-e10