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CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(01): 152-155
DOI: 10.1055/s-0042-1750068
Case Report

Bland Urine Sediment in a Child with Acute Kidney Injury

Rajkumar Kundavaram
1   Department of Pediatrics, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
,
Tanya Sharma
2   Department of Pathology and Lab Medicine, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
,
Deepti Joshi
2   Department of Pathology and Lab Medicine, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
,
Amber Kumar
1   Department of Pediatrics, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
,
Shikha Malik
1   Department of Pediatrics, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
,
Girish C. Bhatt
1   Department of Pediatrics, All India Institute of Medical Sciences Bhopal, Bhopal, Madhya Pradesh, India
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Abstract

Tubulointerstitial nephritis (TIN) or acute interstitial nephritis (AIN) is a renal lesion characterized by inflammatory infiltrate limited to the renal interstitium and tubules. Three-fourths of the cases are drug induced, other causes being systemic and autoimmune diseases, and infections. Various drugs have been implicated, the most common being antibiotics such as β-lactams. Cephalosporins causing AIN have been reported uncommonly, particularly in children. Although renal biopsy confirms the diagnosis, urinalysis provides pertinent diagnostic clues against the backdrop of the clinico-laboratory profile. The presence of white blood cells, white cell casts, and red blood cells in urine sediment have been described in literature. However, a relatively normal urinalysis may be present in some cases and may pose a diagnostic challenge. We present a case of ceftriaxone-induced AIN in a child with bland urine sediment at initial presentation. To the best of our knowledge, this is the first report of ceftriaxone-induced AIN in the pediatric age group.

Keywords

acute interstitial nephritis - acute kidney injury - drug induced - urine sediment

Authors' Contributions

R.K. and T.S. contributed to manuscript writing; G.B. and A.K. contributed to literature review, manuscript editing, clinical data acquisition; D.J. and S.M. contributed to manuscript review.




Publication History

Article published online:
17 August 2022

© 2022. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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