Ultraschall Med 2022; 43(S 01): S29-S30
DOI: 10.1055/s-0042-1749561
Abstracts
Pränatalmedizin

Antenatal characteristics and perinatal outcomes of late-onset fetal growth restriction diagnosed in diabetic pregnancies: a retrospective study

Andrea Dall'Asta
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Ramirez Ruben Zegarra
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
2   Gynecology and Obstetrics, St. Joseph Krankenhaus, Berlin, Germany
3   Technical University of Munich, School of Medicine, Klinikum rechts der Isar, department of gynecology and obstetrics, München
,
Sara Sorrentino
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Beatrice Valentini
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Gabriella M. Celora
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Francesca Frati
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Enrico Corno
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Greta Cagninelli
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
,
Serafina Perrone
4   Materno-Infantile, Universita degli Studi di Parma, Parma, Emilia-Romagna, Italy
,
Silvia Lobmaier
3   Technical University of Munich, School of Medicine, Klinikum rechts der Isar, department of gynecology and obstetrics, München
,
Tullio Ghi
1   Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University ofParma, Parma, Italy.
› Author Affiliations
› Further Information
Also available at
 

Objectives To report the antenatal characteristics and perinatal outcomes of late onset fetal growth restriction(FGR) associated with diabetes mellitus (DM) or gestational diabetes (GDM)

Methods Two-centre retrospective study conducted at two tertiary maternity hospitals. Singleton pregnancies with non-anomalous suspected late-onset FGR diagnosed between 32 and 36 weeks of gestation b ymeans of either abdominal circumference or estimated fetal weight <10 percentile for gestational age or a reduction by over 50 percentiles of the abdominal circumference from an ultrasound scan performed between18 and 32 weeks of gestation were included. The study group was represented by pregnancies where late-onset FGR was associated with DM/GDM; the control group consisted of pregnancies with late-onset FGR not associated with DM/GDM. Adverse perinatal outcome was defined by any of the following: pH <7.1, Apgar at 5min <7, respiratory support at birth, neonatal hypoglycaemia, neonatal jaundice and admission to the NICU

Results Overall, 516 pregnancies complicated by late-onset FGR were included. Among these, DM/GDM was diagnosed in 62 (12.0%). These included 5 (1%) cases of (DM), 42 (8.1%) GDM on diet and 15 (2.9%) of GDM on insulin. Late-onset FGR in DM/GDM was associated with higher maternal BMI at booking (25.3±5.6 vs22.4±4.0; p<0.001) and higher frequency of multiparity (35/63 or 55.6% vs 148/448 or 33.0%; p<0.001) compared to controls; no differences in the perinatal outcomes were noted between late-onset FGR in DM/GDM and controls. Late-onset FGR in women with DM/GDM on insulin was associated with higher incidence of adverse perinatal outcome compared to GDM on diet (17/20, 85%, vs 25/42, 59.5%, p=0.04)

Conclusion In our large cohort of late-onset FGR, we report an increased incidence of adverse perinatal outcome in women with DM/GDM on insulin treatment compared to those with GDM on diet.



Publication History

Article published online:
20 June 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany