Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2023; 36(01): 29-38
DOI: 10.1055/s-0042-1749451

Clinical Communication

Long-Term Assessment of Bone Regeneration in Nonunion Fractures Treated with Compression-Resistant Matrix and Recombinant Human Bone Morphogenetic Protein-2 in Dogs

Andrea Castilla

¹Veterinary Medical Teaching Hospital, Davis, University of California, California, United States

,

Barbro Filliquist

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

,

Mathieu Spriet

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

,

Tanya C. Garcia

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

,

Boaz Arzi

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

³Veterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, California, United States

,

Po-Yen Chou

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

,

Amy S. Kapatkin

²Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States

› Author Affiliations

Abstract

Objective The aim of this study was to assess bone density, bone architecture and clinical function of canine nonunion distal appendicular long bone fractures with a defect treated with fixation, compression-resistant matrix and recombinant human bone morphogenetic protein-2 (rhBMP-2).

Study Design Prospective cohort study with dogs at least 1-year post treatment. Computed tomography was performed and quantitative measurements from previous fracture sites were compared with measurements from contralateral limbs. Subjective evaluation included gait assessment and palpation.

Results Six patients met the inclusion criteria. The rhBMP-2 treated bone exhibited higher density at the periphery and lower density in the centre, similar to the contralateral limb. All patients were weight bearing on the treated limb and all fractures were healed.

Conclusion The rhBMP-2-treated bone underwent restoration of normal architecture and density. Acceptable limb function was present in all patients. The results of this study can serve as a basis for long-term response in treating nonunion fractures in veterinary patients.

Keywords

Keywords

Bone morphogenetic protein 2 - rhBMP-2 - nonunion fracture - compression-resistant matrix - bone regeneration

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