CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0042-1749399
Brief Communication

Systemic Immune-Inflammation Index Predicts Outcomes in Platinum-Resistant Relapsed Ovarian Cancer

Luxitaa Goenka
1   Department of Medical Oncology, JIPMER, Puducherry, India
,
1   Department of Medical Oncology, JIPMER, Puducherry, India
,
1   Department of Medical Oncology, JIPMER, Puducherry, India
,
Smita Kayal
1   Department of Medical Oncology, JIPMER, Puducherry, India
,
1   Department of Medical Oncology, JIPMER, Puducherry, India
› Author Affiliations
Funding The study was supported by JIPMER. No grant number is applicable.

Abstract

We explored the prognostic impact of simple indices that reflect the immunological milieu (neutrophils to lymphocyte ratio [NLR] and systemic immune-inflammation [SII]) in 49 platinum-resistant relapsed ovarian cancer patients. The median progression-free survival (PFS) and overall survival (OS) were 4 and 8 months, respectively. Patients with a lower NLR (≤2.89) had a better PFS (5 vs. 2 months [p = 0.02]) and OS (9 vs. 5 months [p = 0.20]). Factors associated with a worse PFS were NLR > 2.8 (hazard ratio [HR] =2.32, p = 0.02) and SII > 639 (HR =3.70, p = 0.002). SII > 639 independently predicted PFS (HR =4.13, p = 0.03). Future studies should study the validity of inflammatory markers and could consider incorporating it as a biomarker in clinical trials.

Ethical Approval

The study was approved by JIPMER IEC (EC Approval No: JIP/IEC/2019/558).


Supplementary Material



Publication History

Article published online:
28 July 2022

© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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