CC BY 4.0 · Pharmaceutical Fronts
DOI: 10.1055/s-0042-1749327
Original Article

Synthesis and Characterization of Related Substances of Torasemide

Jiong Chen
1   Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, People's Republic of China
,
Wei Ming
1   Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, People's Republic of China
,
De-Hua Fan
2   Wuhan Jianuokang Pharmaceutical Technology Co., Ltd., Wuhan, People's Republic of China
,
Shuang-Xi Gu
1   Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, People's Republic of China
3   Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, People's Republic of China
› Author Affiliations
Funding The supports from the National Natural Science Foundation of China (Grant No. 21877087 and 22074114), the Hubei Provincial Department of Education of China (Grant No. 2021CFB556 and 2020CFB623), Key Laboratory for Green Chemical Process of Ministry of Education (Grant No. GCP20200201), Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Grant No. 40201002), and Wuhan Institute of Technology Teaching Research Project (Grant No. X2017034) are gratefully acknowledged.

Abstract

Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced. In this study, all these related substances, including compounds AE, were synthesized via simple procedures and subsequently characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectrometry. Particularly, a simple synthetic method for compound A has not been found in previous literature. It is worth noting that other related substances could be prepared from compound B in one or two steps. The availability of these related substances could allow for quality control in the process of torasemide.

Supplementary Material



Publication History

Received: 18 February 2022

Accepted: 23 April 2022

Article published online:
30 June 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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