Pathological Spectrum of Vascular Malformations of the Central Nervous System: A Single Institution Experience of a Decade

Shrithi Karanth; Shilpa Rao; Amey Savardekar; Aravind HR; Nupur Pruthi; Arimapamagan Arivazhagan; Dhananjaya I. Bhat; Dwarakanath Srinivas; Bhagvatula Indira Devi; Sampath Somanna; Anita Mahadevan

doi:10.1055/s-0042-1749141

Indian Journal of Neurosurgery, Table of Contents

CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2023; 12(01): 064-070
DOI: 10.1055/s-0042-1749141

Original Article

Pathological Spectrum of Vascular Malformations of the Central Nervous System: A Single Institution Experience of a Decade

Authors

Shrithi Karanth‡^*

¹Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Shilpa Rao‡^*

¹Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Amey Savardekar

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Aravind HR

³Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangaluru, India
Nupur Pruthi

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Arimapamagan Arivazhagan

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Dhananjaya I. Bhat

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Dwarakanath Srinivas

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Bhagvatula Indira Devi

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Sampath Somanna

²Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, India
Anita Mahadevan

¹Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India

Abstract

Background Vascular malformations (VMs) of the central nervous system comprise a variety of lesions that could affect the arteries, veins, or capillaries.

Materials and Methods We analyzed the histopathological features of all the VMs diagnosed at our centre over a decade.

Results Intracranial VM included arteriovenous malformation (AVM) (53%), cerebral cavernous malformations (CCMs) (45%), capillary telangiectasia (2%), venous angioma (0.5%), and arteriovenous fistula (AVF) (0.5%). In spinal VMs, capillary telangiectasia (40%) were the most common, followed by cavernomas (34%), AVF (16%), and AVMs and venous angiomas (5%). Clinical presentation varied from focal deficit to features of raised intracranial tension.

Conclusion Imaging and histopathology plays an important role in the diagnosis and management of VMs. Histopathological examination is essential for characterization of the VMs, which influences the prognosis.

Keywords

vascular malformation - histopathology - CNS

Full Text

References

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