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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2023; 58(03): 378-387
DOI: 10.1055/s-0042-1748947
Revisão Sistemática e Metanálise
Quadril

Eficácia do ibuprofeno após artroplastia total de quadril para prevenção de ossificação heterotópica: Revisão sistemática e metanálise[*]

Article in several languages: português | English
Muhammad Ali Tariq 
1   Departamento de Cirurgia Ortopédica, Dow International Medical College, Karachi, Paquistão
,
Bilal Ahmed 
1   Departamento de Cirurgia Ortopédica, Dow International Medical College, Karachi, Paquistão
,
Shehryar Shaikh 
1   Departamento de Cirurgia Ortopédica, Dow International Medical College, Karachi, Paquistão
,
Hamza Amin 
2   Departamento de Cirurgia Ortopédica, Dr. Ruth K. M. Pfau Civil Hospital, Karachi, Paquistão
,
Syed Uzair Ali 
1   Departamento de Cirurgia Ortopédica, Dow International Medical College, Karachi, Paquistão
› Author Affiliations
Suporte Financeiro Este estudo não recebeu nenhum auxílio ou suporte financeiro.
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Resumo

O objetivo deste estudo foi realizar uma revisão sistemática e metanálise de estudos clínicos randomizados (ECRs) relevantes para determinar o papel do ibuprofeno, sua dose ideal, e a duração do tratamento na prevenção de ossificação heterotópica (OH) após a artroplastia total primária do quadril (ATQ). Uma pesquisa bibliográfica foi feita nos bancos de dados PubMed/MEDLINE e Cochrane Library para a obtenção de ECRs que comparassem o uso de ibuprofeno e de placebo como profilaxia para OH em pacientes submetidos à ATQ. Os principais desfechos deste estudo foram ocorrência geral de OH, classificação de Brooker da OH, e complicações gastrintestinais. No total, 27 artigos foram identificados nos bancos de dados e 4 estudos, com 1.153 pacientes, foram incluídos na análise final. Em comparação ao placebo, o uso de ibuprofeno reduziu a incidência de OH aos 3 e 12 meses de acompanhamento e a incidência de OH Brooker II e III (p < 0,05). No entanto, não houve diferença significativa entre os grupos que receberam ibuprofeno e placebo em termos de interrupção do tratamento devido a complicações gastrintestinais ou da incidência de OH Brooker I e IV (p > 0,05). Os dados existentes indicam que o ibuprofeno é seguro e eficaz na redução da incidência total de OH e de OH Brooker II e III durante o acompanhamento. No entanto, as conclusões são limitadas devido ao pequeno número de estudos; logo, mais estudos clínicos de alta qualidade são necessários para o desenvolvimento de diretrizes em relação à dose e duração ideal da terapia.

Palavras-chave

artroplastia de quadril - ossificação heterotópica - ibuprofeno - metanálise

* Estudo desenvolvido no Departamento de Cirurgia Ortopédica, Dow International Medical College, Karachi, Paquistão




Publication History

Received: 01 September 2021

Accepted: 14 March 2022

Article published online:
27 June 2022

© 2022. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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