J Am Acad Audiol 1999; 10(07): 400-408
DOI: 10.1055/s-0042-1748512
Original Article

Otoacoustic Emissions in Normal-Cycling Females

M. Wende Yellin
Department of Speech Pathology and Audiology, Northern Arizona University, Flagstaff, Arizona
Robert D. Stillman
Program in Human Development and Communication Sciences, The University of Texas at Dallas, Dallas, Texas
› Institutsangaben


The purpose of this study was to determine if the menstrual cycle influences the amplitude of transient (TEOAEs) and distortion-product (DPOAEs) otoacoustic emissions. Thirteen normal-hearing, normal-cycling females were monitored weekly for 12 weeks. TEOAE and DPOAE amplitudes were analyzed to determine if amplitude changes could be detected and correlated to phases of the menstrual cycle. No systematic amplitude changes were observed, demonstrating that evoked OAEs are unaffected by physiologic changes associated with the menstrual cycle.

Abbreviations: ABR = auditory brainstem response, DPOAEs = distortion product otoacoustic emissions, OAEs = otoacoustic emissions, RMANOVA = repeated measures analysis of variance, SOAEs = spontaneous otoacoustic emissions, TEOAEs = transient evoked otoacoustic emissions


Artikel online veröffentlicht:
02. Mai 2022

© 1999. American Academy of Audiology. This article is published by Thieme.

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  • Anderson SD, Kemp DT. (1979). The evoked mechanical responses in laboratory primates. Arch Otolaryngol 244: 47–54.
  • Antonelli A, Grandori F. (1986). Long term stability, influence of the head position and modeling considerations for evoked otoacoustic emissions. Scand Audiol Suppl 25: 97–108.
  • Baker MA, Weiler EM. (1977). Sex of listener and hormonal correlates of auditory thresholds. Br J Audiol 11: 65–68.
  • Bell A. (1992). Circadian and menstrual rhythms in frequency variations of spontaneous otoacoustic emissions from human ears. Hear Res 58: 91–100.
  • Bilger RC, Matthies ML, Hammel DR, Demorest ME. (1990). Genetic implications of gender differences in the prevalence of spontaneous otoacoustic emissions. J Speech Hear Res 33: 418–432.
  • Bonfils P, Uziel Α. (1988). Evoked otoacoustic emissions in patients with acoustic neuromas. Am J Otol 9: 412–417.
  • Cane MA, Lutman ME, O'Donoghue GM. (1994). Transiently evoked otoacoustic emissions in patients with cerebellopontine angle tumors. Am J Otol 15: 207–216.
  • Cox JR. (1980). Hormonal influence on auditory function. Ear Hear 1:219–222.
  • Davis MJ, Ahroon WA. (1982). Fluctuations in susceptibility to noise-induced temporary threshold shift as influenced by the menstrual cycle. J Auditory Res 22: 173–187.
  • Dehan CP, Jerger JF. (1990). Analysis of gender differences in the auditory brainstem response. Laryngoscope 100: 18–24.
  • Elkind-Hirsch KE, Stoner WR, Stach ΒΑ, Jerger JF. (1992). Estrogen influences auditory brainstem responses during the normal menstrual cycle. Hear Res 60: 143–148.
  • Elkind-Hirsch KE, Wallace E, Malinak LR, Jerger JF. (1994). Sex hormones regulate ABR latency. Otolaryngol Head Neck Surg 110: 46–52.
  • Franklin DJ, Lonsbury-Martin BL, Stagner BB, Martin GK. (1991). Altered susceptibility of 2f1-f2 acoustic-distortion products to the effects of repeated noise exposure in rabbits. Hear Res 53: 185–208.
  • Franklin DJ, McCoy MJ, Martin GK, Lonsbury-Martin BL. (1992). Test/retest reliability of distortion-product and transiently evoked otoacoustic emissions. Ear Hear 13: 417–429.
  • Gaskill SA, Brown AM. (1990). The behavior of the acoustic distortion product 2fl-2f2 from the human ear and its relation to auditory sensitivity. J Acoust Soc Am 88: 821–839.
  • Haggerty HS, Lusted HS, Morton SC. (1993). Statistical quantification of 24-hour and monthly variabilities of spontaneous otoacoustic emission frequency in humans. Hear Res 70: 31–49.
  • Harris FP, Probst R, Wenger R. (1991). Repeatability of transiently evoked otoacoustic emissions in normally hearing humans. Audiology 30: 135–141.
  • Johnsen NJ, Elberling C. (1982). Evoked acoustic emissions from the human ear. II. Normative data in young adults and influence of posture. Scand Audiol 12: 69–77.
  • Kemp DT. (1978). Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am 64: 1386–1391.
  • Kemp DT. (1982). Cochlear echoes: implications for noise-induced hearing loss. In: Hammernik RP, Henderson D, Salvi R, eds. New Perspectives on Noise-Induced Hearing Loss. New York: Raven Press, 189–206.
  • Kemp DT. (1986). Otoacoustic emissions travelling waves and cochlear mechanisms. Hear Res 22: 95–104.
  • Lanctot CA. (1979). Natural family planning. Clin Obstet Gynecol 6:109–127.
  • Lasky RE, Snodgrass E, Hecox K. (1994). Distortion-product otoacoustic emission input/output functions as a function of frequency in human adults. J Am Acad Audiol 5: 183–194.
  • Long GR, Tubis A. (1988). Modification of spontaneous and evoked otoacoustic emissions and associated psy-choacoustic microstructure by aspiring consumption. J Acoust Soc Am 84: 1343–1353.
  • Lonsbury-Martin BL, Martin GK. (1990). The clinical utility of distortion-product otoacoustic emissions. Ear Hear 11: 144–154.
  • Lonsbury-Martin BL, Martin GK, McCoy MJ, Whitehead ML. (1995). New approaches to the evaluation of the auditory system and a current analysis of otoacoustic emissions. Otolaryngol Head Neck Surg 112: 50–63.
  • Lutman ME, Mason SM, Sheppard S, Gibbin KP. (1989). Differential diagnostic potential of otoacoustic emissions: a case study. Audiology 28: 205–210.
  • Marshall J. (1968). A field trial of the basal-body-temperature method of regulating births. Lancet 2: 8–10.
  • Martin GK, Probst R, Lonsbury-Martin BL. (1990). Otoacoustic emissions in human ears: normative findings. Ear Hear 11: 121–127.
  • Maurer J, Hinni M, Beck A, Mann W. (1995). Effects of contralateral white noise stimulation on transitory evoked otoacoustic emissions in patients with acoustic neuroma. Otolaryngol Head Neck Surg 112: 369–374.
  • McAlpine D, Johnstone BM. (1990). The ototoxic mechanism of cisplatin. Hear Res: 47: 191–204.
  • McFadden D. (1993). A speculation about the parallel ear asymmetries and sex differences in hearing sensitivity and otoacoustic emissions. Hear Res 68: 143–151.
  • Miller NH, Gould WJ. (1967). Fluctuating sensorineural hearing impairment associated with the menstrual cycle. J Auditory Res 7: 373–385.
  • Nelson DA, Kimberley BR (1992). Distortion-product emissions and auditory sensitivity in human ears with normal hearing and cochlear hearing loss. J Speech Hear Res 35: 1142–1159.
  • Norton SJ. (1994). Emerging role of evoked otoacoustic emissions in neonatal hearing screening. Am J Otol 15: 4–12.
  • O'Brien AJ. (1994). Temperature dependency of the frequency and level of spontaneous otoacoustic emission during fever. Br J Audiol 28: 281–290.
  • Penner MJ. (1995). Frequency variation of spontaneous otoacoustic emissions during a naturally occurring menstrual cycle amenorrhea and oral contraception: a brief report. Ear Hear 16: 428–432.
  • Penner MJ, Brauth SE, Jastreboff PJ. (1994). Covariation of binaural concurrently-measured spontaneous otoacoustic emissions. Hear Res 73: 190–194.
  • Penner MJ, Glotzbach L. (1994). Covariation of tinnitus pitch and the associated emission: a case study. Otolaryngol Head Neck Surg 110: 304–309.
  • Picton TW, Stapells DR, Campbell KB. (1981). Auditory evoked potentials from the human cochlea and brainstem. J Otolaryngol Suppl 9: 1–41.
  • Prieve BA, Gorga MP, Schmidt Α, Neely S, Peters J, Schultes L, Jesteadt W. (1993). Analysis of transient-evoked otoacoustic emissions in normal-hearing and hearing-impaired ears. J Acoust Soc Am 93: 3308–3319.
  • Probst R, Coats AC, Martin GK, Lonsbury-Martin BL. (1986). Spontaneous click- and toneburst-evoked otoacoustic emissions from normal ears. Hear Res 21: 261–285.
  • Probst R, Harris FP, Hauser R. (1993). Clinical monitoring using otoacoustic emissions. Br J Audiol 27: 85–90.
  • Probst R, Lonsbury-Martin BL, Martin GK. (1991). A review of otoacoustic emissions. J Acoust Soc Am 89: 2027–2067.
  • Robinette MS. (1992). Otoacoustic emissions in cochlear vs. retrocochlear auditory dysfunction. Hear J 45: 32–34.
  • Robinette MS, Facer GW. (1991). Evoked otoacoustic emissions in differential diagnosis: a case report. Otolaryngol Head Neck Surg 105: 120–123.
  • Roede J, Harris FP, Probst R, Xu L. (1993). Repeatability of distortion product otoacoustic emissions in normally hearing humans. Audiology 32:273–281.
  • Royston JP, Abrams RM. (1980). An objective method for detecting the shift in basal body temperature in women Biometrics 36:217–224.
  • Strickland EA, Burns EM, Tubis A. (1985). Incidence of spontaneous otoacoustic emissions in children and infants. J Acoust Soc Am 78:931–935.
  • Swanson SJ, Dengerink HA. (1988). Changes in pure-tone thresholds and temporary threshold shifts as a function of menstrual cycle and oral contraceptives. J Speech Hear Res 31: 569–574.
  • Sutton LA, Lonsbury-Martin BL, Martin GK, Whitehead ML. (1994). Sensitivity of distortion-product otoacoustic emissions in humans to tonal over-exposure: time course of recovery and effects of lowering L2. Hear Res 75: 161–174.
  • Vedantam R, Musiek FE. (1991). Click evoked otoacoustic emissions in adult subjects: standard indices and test-retest reliability. Am J Otol 12: 435–442.
  • Wable J, Collet L. (1994). Can synchronized otoacoustic emissions really be attributed to SOAEs? Hear Res 80: 141–145.
  • White KR, Maxon AB, Behrens TR, Blackwell PM, Vohr BR. (1992). Neonatal hearing screening using evoked otoacoustic emissions: the Rhode Island hearing assessment project. In: Bess FH, Hall JW, eds. Screening Children for Auditory Function. Nashville, TN: Bill Wilkerson Center Press, 207-228.
  • White KR, Vohr BR, Behrens TR. (1993). Universal newborn hearing screening using transient evoked otoacoustic emissions: results of the Rhode Island hearing assessment project. Semin Hear 14: 18–29.
  • Whitehead ML, Baker RJ, Wilson JP. (1989). The bilateral symmetry and sex asymmetry of spontaneous otoacoustic emission (SOAE) incidence in human ears Br J Audiol 223: 149.
  • Zorowka PG, Schmitt HJ, Gutjahr P. (1993). Evoked otoacoustic emissions and pure tone threshold audiometry in patients receiving cisplatinum therapy. Int J Pediatr Otorhinolaryngol 25: 73–80.
  • Zurek PM, Clark WW, Kim DO. (1982). The behavior of acoustic distortion products in the ear canals of chinchillas with normal or damaged ears. J Acoust Soc Am 72: 774–780.