Mechanism of Olibanum and Myrrha for the Acute Soft Tissue Injury Based on Network Pharmacology

Abstract

Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury (ASTI) by network pharmacology and to clarify their mechanisms.

Methods The main chemical constituents and the targets of olibanum and myrrha were obtained by using traditional Chinese medicine systems pharmacology database and analysis platform database. The disease targets of ASTI were searched by GeneCards. The intersection targets of herbs and diseases were selected for protein interaction analysis, protein–protein interaction network was constructed, and potential protein functional modules in the network were explored. A compound–target–disease network was constructed using Cytoscape3.8.2 software. The targets were analyzed by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on the Metascape database.

Results The core active components of olibanum and myrrha were quercetin, β-sitosterol, and stigmasterol. The core targets were PGR, NCOA2, PTGS2, PRKCA, and NR3C2. Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications might play a potential role in olibanum and myrrha in the treatment of ASTI.

Conclusion Olibanum and myrrha have the characteristics of multiple components, multiple targets, and overall regulation in the treatment of ASTI.

Keywords

olibanum and myrrha - acute soft tissue injury - network pharmacology

Credit Autorship Contribution Statement

Miao Tan: Data collection and curation, formal analysis, software, and writing original draft. Yan Cheng: Conceptualization, methodology, supervision, and writing - review & editing.

Publikationsverlauf

Eingereicht: 08. Januar 2021

Angenommen: 23. Februar 2022

Artikel online veröffentlicht:
07. Juli 2022

• References

• 1 Wang ZX. Clinical observation of acute soft tissue injury treated by integrated Traditional Chinese and Western medicine. J Emerg Tradit Chin Med 2014; 10: 1930-1931
• 2 Dong F, Xue C, Wang Y. et al. Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury. Sci Rep 2017; 7: 40584
• 3 Si YH, Ma Y, Guo Y. et al. Ma Yong's experience in treating acute tendon injury with activating blood circulation and promoting diuresis. Chin J Tradit Chin Med and Pharm. 2018; 33 (09) 3951-3954
• 4 Jiang GP, Xie XW, Gu YB. et al. Treatment of acute soft tissue injury with traditional Chinese medicine. J Emerg Tradit Chin Med 2015; 24 (07) 1209-1211
• 5 Yu W, Li M, Zhang CW. Zhang Xichun's experience in using olibanum and myrrh. J Basic Clin Med 2021; 27 (08) 1238-1240
• 6 Network Pharmacology Evaluation Method Guidance. World. Chin Med 2021; 16 (04) 527-532
• 7 Xia TW, Zhou GW, Liu JZ. et al. Exploration on mechanism of Bushen Huoxue decoction in treatment of osteonecrosis of femoral head based on network pharmacology. Shandong J Tradit Chin Med 2021; 01: 25-31
• 8 Bardou P, Mariette J, Escudié F, Djemiel C, Klopp C. jvenn: an interactive Venn diagram viewer. BMC Bioinformatics 2014; 15: 293
• 9 Algafly AA, George KP. The effect of cryotherapy on nerve conduction velocity, pain threshold and pain tolerance. Br J Sports Med 2007; 41 (06) 365-369 , discussion 369
• 10 Van den Bekerom MP, Struijs PA, Blankevoort L, Welling L, van Dijk CN, Kerkhoffs GM. What is the evidence for rest, ice, compression, and elevation therapy in the treatment of ankle sprains in adults?. J Athl Train 2012; 47 (04) 435-443
• 11 Hotfiel T, Hoppe MW, Heiss R. et al. Quantifiable contrast-enhanced ultrasound explores the role of protection, rest, ice (cryotherapy), compression and elevation (PRICE) therapy on microvascular blood flow. Ultrasound Med Biol 2021; 47 (05) 1269-1278
• 12 Li CF, Zhang JL. Pondering about the treatment principle of acute soft tissue injury. Fujian Sports Sci Techn 2018; 3: 41-43
• 13 Bleakley CM. Acute soft tissue injury management: past, present and future. Phys Ther Sport 2013; 14 (02) 73-74
• 14 Dubois B, Esculier JF. Soft-tissue injuries simply need PEACE and LOVE. Br J Sports Med 2020; 54 (02) 72-73
• 15 Jiang S, Chen Z, Lai W. et al. Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation. Biosci Rep 2020; 40 (12) BSR20201981
• 16 Yang ZX, Dou QL. Clinical study of Xuan Huang ointment on acute soft tissue injury. Asia-Pacific Tradit Med 2017; 2: 144-145
• 17 Fan JC, Dou QL. Clinical observation of Xuan Huang ointment in treatment of acute ankle sprain. J Pract Tradit Chin Med 2017; 1: 80-81
• 18 Cheng Y, Zhao XY, Wang MJ. et al. Influence of Xuan Huang ointment on the content of IL-1β,TNF-α in part of the injury tissues of rats with acute soft tissue injury. Shaanxi J Tradit Chin Med 2019; 1: 9-11
• 19 Cheng Y, Zhao CW, Fan JC. et al. Effect of Xuan Huang Ointment on hemorheology of rats with acute soft tissue injury. Mod Tradit Chin Med. 2020; 40 (05) 15-17
• 20 Cheng Y, Zhao CW, Li H. et al. Experimental study on the effect Xuan Huang ointment on immune function in rats with acute soft tissue injury. Shaanxi J Tradit Chin Med 2001; 03: 284-287
• 21 Chen W, Xiao HQ, Wang YL. et al. Study on mechanism of Qili powder in rehabilitation of acute sports injury based on network pharmacology. Lishizhen Med Mater Med Res. 2021; 32 (04) 832-836
• 22 Gao L, Huang SY, Chen LH. et al. A preliminary study on promoting effect of frankincense and myrrh volatile oil on HaCaT cell uptake of alkaloids in Jiufen powder and its mechanism. Chin Tradit Herbal Drugs 2021; 52 (08) 2357-2364
• 23 Yan HY, Guo JH, Wang JJ. et al. Clinical observation on the treatment of acute soft tissue injury of knee joint by Huo Luo Xiao Ling pills decoction. J Pract Tradit Chin Med. 2019; 06: 640-641
• 24 Feng YL, Li H, Liu J. et al. Research progress of quercetin. Chin J Chin Mater Med. 2021; 46 (20) 5185-5193