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DOI: 10.1055/s-0042-1746444
Role of biomamerks in diagnostics of reflux-associated diseases of the larynx
Introduction Reasons of occurence of lesions of the larynx are multifactorial, herewith several authors withdraw the leading role to laryngo-pharyngeal reflux(LPR) (Shimazu,2014; C. Storck, 2009: K.Tsunoda, 2007).
Aim of the research to study expression of adhesive protein E-cadherin and proliferative activity of laryngeal epithelial cells in patients with LPR.
Materials and methods 86 patients with laryngeal granuloma (“granulation polyps”) were examined, wherein 45 patients had authentically diagnosed LPR. In 41 patients, development of laryngeal granulomas were not associated with LPR.
Results and discussion The difference in morphology of granulomas in patients with LPR and other reasons were not identified. For the further immunohistochemichal research 20 patients with LPR and 20 patients without LPR were selected.
Significant differences in expression of molecules of intercellular adhesion in patients with LPR and without it were discovered. We admitted detection of E-cadherin expression reduction or full absence of protein in patients with LPR, while all second-group patients demonstrated normal expression of the marker.
Conclusions Applying markers of adhesive activity appears to be perspective in studying pathogenesis of LPR.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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