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DOI: 10.1055/s-0042-1744423
Therapeutic Effect of Autologous Activated Platelet-rich Plasma Therapy on Mid-dermal to Full-thickness Burns: A Case Series
Abstract
Although modern medicine has made great strides in the management of burn injuries, associated complications such as pain, infection, dyspigmentation, and scarring have yet to be fully dealt with. Although skin grafting and meshing are routinely performed on burn patients, this method poses a risk for adverse effects. Activated autologous platelet-rich plasma (aaPRP), which is increasingly used in the field of plastic surgery, contains growth factors beneficial for wound regeneration. Seven cases of burns with varying severity and conditions that were treated with intralesional subcutaneous injection and intravenous aaPRP are presented and discussed herein. This case series indicates that subcutaneous and intravenous aaPRP is a safe procedure with the potential to be an alternative when skin grafting cannot be done or as an adjunct treatment to skin grafting.
Author Contributions
Conceptualization: K.K. Investigation: K.E., J.A.B., and P.H. Resources: K.K. Writing–original draft: K.K., K. E., J.A.B., P.H., H.A., and P.M.S. Writing–review and editing: K.K., K.E., J.A.B., P.H., and H.A.
Ethical Approval
This study was approved by the Health Research Ethics Committee, University of Indonesia, and Cipto Mangunkusumo Hospital (No. 0249/UN2.F1/ETIK/2018) and performed in accordance with the principles of the Declaration of Helsinki.
Patient Consent
Informed consent was obtained from the patients.
Publication History
Article published online:
27 May 2022
© 2022. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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