Semin Plast Surg 2022; 36(01): 043-047
DOI: 10.1055/s-0042-1744282
Review Article

Use of Biologic Agents in Extremity Reconstruction

Andrew E. Grush
1   Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Surgery, Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas
,
Monal Depani
3   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
,
Matthew J. Parham
1   Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas
2   Department of Surgery, Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas
,
Valeria Mejia-Martinez
3   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
,
Alexandra Thornton
3   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
,
Douglas M. Sammer
3   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
› Author Affiliations

Abstract

Skin and soft tissue defects of the lower extremity present a unique challenge for the reconstructive surgeon. Successful repair of the lower extremity relies not only on strong anatomical knowledge and surgical expertise, but also on careful consideration of the numerous preoperative factors and indications that may alter the patient's response to operative management. While many of these injuries result from burns, avulsive trauma, diabetes, or vascular insufficiencies, a significant portion can be associated with resection of neoplastic pathologies. This review outlines the uses, indications, and considerations for biologic wound agents in reconstructing skin and soft tissue defects of the lower extremity following Mohs micrographic surgery.



Publication History

Article published online:
12 April 2022

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