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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(01): e158-e165
DOI: 10.1055/s-0042-1744164
Systematic Review

Neurological Complications in Benign Parapharyngeal Space Tumors – Systematic Review and Meta-Analysis

Muhammad Faisal 
1   Shaukat Khanum Memorial Cancer Hosital and Research Centre, Lahore, Pakistan
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
,
Rudolf Seemann 
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
,
Gregor Fischer
3   Department of ENT, Danube University, Krems Faculty of Health and Medicine, Krems, Niederösterreich, Austria
,
Claudia Lill 
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
,
Sasan Hamzavi
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
,
Arno Wutzl
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
,
Boban M. Erovic 
2   Department of Head and Neck Surgery, Evangelisches Krankenhaus Vienna, Vienna, Austria
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Abstract

Introduction Parapharyngeal space tumors with complex anatomy and diverse histology have remained a challenging phenomenon for treating physicians.

Objectives We have conducted a comprehensive web search on the PubMed, Web of Science, EMBASE, Cochrane Library, Biomedical Literature Database (CBM), and Clinicaltrials.gov databases to determine the factors that are associated with postoperative complications in parapharyngeal space tumors.

Data Synthesis Two researchers reviewed all identified articles independently with a third reviewer for adjudication. Patient demographics and other clinicopathological characteristics were explored. The systematic review has identified 631 benign parapharyngeal space tumors with neurogenic and salivary tissue histology in 13 studies, with a mean age of 42.9 ± 7.76 years old and a median follow-up of 40.98 ± 19.1 months. Salivary gland (50.8%) and neurogenic (49.1%) tumors were the most common histological entities. Tumor size, location, histology, deep parotid lobe involvement, and proximity to great vessels or to the skull base were the deciding factors in selecting the surgical approach. The factors considered to select the surgical approach do not seem to have a correlation with the outcome in terms of neurological sequalae (p = 0.106). Tumors with neurogenic histology have significantly increased chances of developing neurological complication (OR 6.07; p = 0.001).

Conclusion Neurologic complications are significantly associated with neurogenic benign tumors rather than surgical approach.

Keywords

cancer of head and neck - parapharyngeal space - neurologic manifestations


Publication History

Received: 10 February 2021

Accepted: 16 June 2021

Article published online:
21 October 2022

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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