Download PDF
CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2023; 42(01): e79-e84
DOI: 10.1055/s-0042-1743556
Case Report

Oncocytic Meningioma: Case Report of a Rare Meningioma Variant

Meningioma oncocítico: Relato de caso de variante rara de meningioma
Yuri Reis Casal 
1   Division of Neuropathology, Department of Pathology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Lívia Porto Teixeira 
2   Division of Neuroradiology, Department of Radiology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Gabriela Alencar Bandeira 
2   Division of Neuroradiology, Department of Radiology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Matheus Moreli Porceban 
3   Department of Neurosurgery, Universidade de São Paulo, São Paulo, SP, Brazil
,
Wellingson Silva Paiva 
3   Department of Neurosurgery, Universidade de São Paulo, São Paulo, SP, Brazil
,
Luis Filipe de Souza Godoy 
2   Division of Neuroradiology, Department of Radiology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Vitor Nagai Yamaki 
3   Department of Neurosurgery, Universidade de São Paulo, São Paulo, SP, Brazil
,
Leandro Tavares Lucato 
2   Division of Neuroradiology, Department of Radiology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Venâncio Avancini Ferreira Alves 
1   Division of Neuropathology, Department of Pathology, Universidade de São Paulo, São Paulo, SP, Brazil
,
Fernando Pereira Frassetto 
1   Division of Neuropathology, Department of Pathology, Universidade de São Paulo, São Paulo, SP, Brazil
› Author Affiliations
› Further Information
   Permissions and Reprints

Abstract

Oncocytic meningioma has been first identified in 1997 as a rare meningioma variant, composed predominantly of large meningothelial cells with abundant intracytoplasmic mitochondria. Here, we describe a 34-year-old male patient presenting with 2 weeks of progressive holocranial headache. Brain magnetic resonance imaging (MRI) revealed an extra axial solid-cystic expansive lesion in the left parieto-occipital parasagittal region, with intense vascularization. Histological and immunohistochemical analysis established the diagnosis. We also review briefly the pathological and radiological findings of this rare variant of meningioma as described in the literature.

Resumo

O meningioma oncocítico foi identificado pela primeira vez em 1997 como uma variante rara do meningioma, composta predominantemente por grandes células meningoteliais com abundantes mitocôndrias intracitoplasmáticas. Aqui, descrevemos um paciente do sexo masculino de 34 anos apresentando cefaleia holocraniana progressiva de 2 semanas. A ressonância magnética (RM) do cérebro revelou lesão expansiva sólido-cística extra-axial em região parassagital parieto-occipital esquerda, com intensa vascularização. A análise histológica e imuno-histoquímica estabeleceu o diagnóstico. Também revisamos brevemente os achados patológicos e radiológicos desta variante rara de meningioma, conforme descrito na literatura.

Keywords

meningioma - mitochondria - pathology

Palavras-chave

meningioma - mitocôndrias - patologia


Publication History

Received: 17 July 2021

Accepted: 13 October 2021

Article published online:
05 September 2022

© 2022. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • References

  • 1 Marucci G, Betts CM, Frank G, Foschini MP. Oncocytic meningioma: report of a case with progression after radiosurgery. Int J Surg Pathol 2007; 15 (01) 77-81
    CrossrefPubMedGoogle Scholar
  • 2 Louis D, Ohgaki H, Wiestler O. et al. WHO Classification of Tumours of the Central Nervous System (Revised 4th edition). IARC; Lyon: 2016
    Google Scholar
  • 3 Caldarella A, Buccoliero AM, Marini M, Taddei A, Mennonna P, Taddei GL. Oncocytic meningioma: a case report. Pathol Res Pract 2002; 198 (02) 109-113
    CrossrefPubMedGoogle Scholar
  • 4 Giangaspero F, Cenacchi G. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Semin Diagn Pathol 1999; 16 (02) 91-97
    PubMedGoogle Scholar
  • 5 Zunarelli E, Tallarico E, Valentini A, Maiorana A. Oncocytic meningioma: study of eight new cases and analysis of 13 reported cases. Pathology 2010; 42 (06) 587-589
    CrossrefPubMedGoogle Scholar
  • 6 Sasagawa Y, Tachibana O, Iida T, Iizuka H. Oncocytic meningioma presenting with intratumoral hemorrhage. J Clin Neurosci 2013; 20 (11) 1622-1624
    CrossrefPubMedGoogle Scholar
  • 7 Roncaroli F, Riccioni L, Cerati M. et al. Oncocytic meningioma. Am J Surg Pathol 1997; 21 (04) 375-382
    CrossrefPubMedGoogle Scholar
  • 8 Niiro M, Ishimaru K, Hirano H, Yunoue S, Kuratsu J. Clinico-pathological study of meningiomas with haemorrhagic onset. Acta Neurochir (Wien) 2003; 145 (09) 767-772
    CrossrefPubMedGoogle Scholar
  • 9 Zheng J, Geng M, Shi Y, Jiang B, Tai Y, Jing H. Oncocytic meningioma: a case report and review of the literature. Surg Oncol 2013; 22 (04) 256-260
    CrossrefPubMedGoogle Scholar
  • 10 Nagai Yamaki V, de Souza Godoy LF, Alencar Bandeira G. et al. Dural-based lesions: is it a meningioma?. Neuroradiology 2021; 63 (08) 1215-1225
    CrossrefPubMedGoogle Scholar
  • 11 Lyndon D, Lansley JA, Evanson J, Krishnan AS. Dural masses: meningiomas and their mimics. Insights Imaging 2019; 10 (01) 11
    CrossrefPubMedGoogle Scholar
  • 12 Cannon J. The significance of hurthle cells in thyroid disease. Oncologist 2011; 16 (10) 1380-1387
    CrossrefPubMedGoogle Scholar
  • 13 Máximo V, Sobrinho-Simões M. Mitochondrial DNA ‘common’ deletion in Hürthle cell lesions of the thyroid. J Pathol 2000; 192 (04) 561-562
    CrossrefPubMedGoogle Scholar
  • 14 Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M. The biology and the genetics of Hurthle cell tumors of the thyroid. Endocr Relat Cancer 2012; 19 (04) R131-R147
    CrossrefPubMedGoogle Scholar
  • 15 Rogers L, Barani I, Chamberlain M. et al. Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 2015; 122 (01) 4-23
    CrossrefPubMedGoogle Scholar