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Thromb Haemost 2022; 122(09): 1532-1541
DOI: 10.1055/s-0042-1743475
Stroke, Systemic or Venous Thromboembolism

One Year Prevalence of Venous Thromboembolism in Hospitalized COVID-19 Patients in France: Patients' Characteristics, Time Trends, and Outcomes

Amélie Gabet
1   Cardiovascular Division, Department of Non-Communicable Diseases, Santé Publique France, Saint-Maurice (94), France
,
Clémence Grave
1   Cardiovascular Division, Department of Non-Communicable Diseases, Santé Publique France, Saint-Maurice (94), France
,
Philippe Tuppin 
2   Department of Studies Strategy and Statistics, Caisse Nationale d'Assurance Maladie, Paris, France
,
Valérie Olié
1   Cardiovascular Division, Department of Non-Communicable Diseases, Santé Publique France, Saint-Maurice (94), France
,
Joseph Emmerich
3   Department of Vascular Medicine, Groupe Hospitalier Paris Saint-Joseph, Université de Paris, INSERM CRESS 1153, Paris, France
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Abstract

Background Patients hospitalized with coronavirus disease-2019 (COVID-19) are at high risk of deep venous thrombosis (DVT) and pulmonary embolism (PE).

Objectives The aims were to provide time trends in the 2020 nation-wide prevalence of venous thromboembolism (VTE) in patients hospitalized with a COVID-19 diagnosis in France, and to describe in-hospital and up to 30-day postdischarge death.

Methods All patients hospitalized in France with a COVID-19 diagnosis in 2020 were selected. Crude and age-adjusted prevalence of VTE and PE was computed by 4-week intervals and for the overall study period using Poisson regression. Time trends in in-hospital and 30-day postdischarge case-fatality rates were evaluated by comparing each 4-week intervals to weeks 10 to 14 corresponding to the first part of the first lockdown using logistic regression models.

Results Among the 287,638 patients hospitalized with a COVID-19 diagnosis in 2020 in France, 14,985 (5.2%) had a concomitant VTE, with 10,453 (3.6%) having PE and 4,532 (1.6%) having DVT. In patients admitted to intensive care units, the crude prevalence of VTE and PE reached 16.1 and 11.0% respectively during the first lockdown. After adjustment, the prevalence of VTE and PE decreased during the year 2020 but a rebound was observed during the second lockdown. In-hospital case-fatality rates among hospitalized COVID-19 patients with PE globally decreased between the first and the second epidemic waves.

Conclusion Our study showed a decrease in the incidence of symptomatic VTE and PE in hospitalized COVID-19 patients, and a decreased time trend of outcomes during the second wave compared with the first one.

Keywords

venous thromboembolism - pulmonary embolism - COVID-19 - hospitalization - case-fatality

Author Contributions

A.G. directed the research, wrote the manuscript, and performed the statistical analyses; C.G. contributed to statistical analyses, discussion, and reviewed the manuscript; P.T., J.E., and V.O. directed the research, contributed to discussion, and reviewed the manuscript. All the authors have read and approved the manuscript and its publication as an original research article.


Supplementary Material



Publication History

Received: 12 November 2021

Accepted: 20 January 2022

Article published online:
14 March 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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