Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family

Abstract

Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19.

Keywords

COVID-19 - mannose-binding lectin 2 - polymorphism

Availability of Data and Materials

The authors declare that data supporting the findings of this study are available within the referenced articles.

Ethical Approval and Consent to Participate

Ethical committee approval was received (Faculty of Medicine, Istanbul University, approval date and number: 21/05/2020-84539) and a written consent was obtained from all patients for both sampling and publishing. The experimental procedures were based on the Declaration of Helsinki and relevant institutional regulations.

Publication History

Received: 09 December 2021

Accepted: 29 December 2021

Article published online:
25 February 2022

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