CC BY 4.0 · Eur J Dent 2023; 17(01): 161-172
DOI: 10.1055/s-0042-1743156
Original Article

Assessment of Oral Health and Healthy Habits in Adult Patients with Congenital Hemophilia

Sylwia Czajkowska
1   Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland
,
Joanna Rupa-Matysek
2   Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
,
Lidia Gil
2   Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
,
1   Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland
› Author Affiliations

Abstract

Objectives The objective of our study was to assess the current knowledge, the oral health status, and the pro-health needs of patients with hemophilia.

Materials and Methods The study included 77 patients with known hemophilia. The study included the assessment of dental indicators related to caries incidence (decayed, missing, and filled teeth [DMFT] and decayed, missing, and filled permanent teeth or surfaces [DMFS]), caries treatment (treatment index), oral hygiene status (Approximal Plaque Index [API] and simplified oral hygiene index [OHI-S]), and periodontal status (bleeding on probing [BoP]). A questionnaire addressed symptoms of hemorrhagic diathesis and health-promoting habits. The influence of routine management (“on-demand” vs. prophylactic therapy), type of hemophilia (A, B), and severity of clotting factor deficiency (mild, moderate, or severe) on oral health was assessed.

Statistical Analysis The tests used in the study were Shapiro–Wilk, Mann–Whitney, Kruskal–Wallis, and Dunn's tests. The level of significance was set at p < 0.05.

Results Patients with hemophilia showed a higher prevalence of caries compared with patients without hemorrhagic diathesis (DMFT 14 and 9, and DMFS 30 and 15, respectively), and they also presented a higher bleeding index value during probing and worse effectiveness of hygienic interdental procedures. The type of therapy and secondary prophylaxis used and the type and severity of hemophilia did not affect the oral health status.

Conclusions Patients with hemophilia have an increased risk of developing dental caries. Undertaking educational activities related to the prevention of oral diseases is necessary to improve oral health.



Publication History

Article published online:
02 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Centers for Disease Control and Prevention. What is hemophilia?. Accessed September, 18, 2021 at: https://www.cdc.gov/ncbddd/hemophilia/facts.html
  • 2 Puy C, Rigg RA, McCarty OJ. The hemostatic role of factor XI. Thromb Res 2016; 141 (2, Suppl 2): S8-S11
  • 3 World Federation of Hemophilia. World Bleeding Disorders Registry 2019 Data Report. Accessed September 18, 2021 at: http://www1.wfh.org/publications/files/pdf-1786.pdf
  • 4 Karaman K, Akbayram S, Garipardıç M, Öner AF. Diagnostic evaluation of our patients with hemophilia A: 17-year experience. Turk Pediatri Ars 2015; 50 (02) 96-101
  • 5 Shastry SP, Kaul R, Baroudi K, Umar D, Hemophilia A. Hemophilia A: dental considerations and management. J Int Soc Prev Community Dent 2014; 4 (Suppl. 03) S147-S152
  • 6 Cox DP, Solar A, Huang J, Chigurupati R. Pseudotumor of the mandible as first presentation of hemophilia in a 2-year-old male: a case report and review of jaw pseudotumors of hemophilia. Head Neck Pathol 2011; 5 (03) 226-232
  • 7 Rodriguez-Merchan EC. Hemophilic pseudotumors: diagnosis and management. Arch Bone Jt Surg 2020; 8 (02) 121-130
  • 8 Kwon AY, Huh KH, Yi WJ. et al. Haemophilic pseudotumour in two parts of the maxilla: case report. Dentomaxillofac Radiol 2016; 45 (06) 20150440
  • 9 Windyga J, Chojnowski K, Klukowska A. et al. Part I: Guidelines on the management of Haemophilia A and B without factor VIII or IX inhibitors (updated edition). Acta Haematol Pol 2016; 47 (02) 86-114 DOI: 10.1016/j.achaem.2016.04.009.
  • 10 Windyga J. Rekombinowane Czynniki Krzepnięcia Krwi. Acta Haematol Pol 2004; 35 (01) 1-10
  • 11 Greene JC, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc 1964; 68: 7-13
  • 12 Kumar M, Pai KM, Kurien A, Vineetha R. Oral hygiene and dentition status in children and adults with hemophilia: a case-control study. Spec Care Dentist 2018; 38 (06) 391-394
  • 13 Reddy KS, Reddy NV, Niharika P, Reddy MA, Danaeswari V, Noorjahan MD. Oral health status and treatment needs among hemophilic children in Hyderabad, Telangana, India. Int J Clin Pediatr Dent 2019; 12 (01) 30-32
  • 14 Mielnik-Błaszczak M. Evaluation of dentition status and oral hygiene in Polish children and adolescents with congenital haemorrhagic diatheses. Int J Paediatr Dent 1999; 9 (02) 99-103
  • 15 Nagaveni NB, Arekal S, Poornima P, Hanagawady S, Yadav S. Dental health in children with congenital bleeding disorders in and around Davangere: a case-control study. J Indian Soc Pedod Prev Dent 2016; 34 (01) 76-81
  • 16 Baskirt E, Albayrak H, Ak G, Erdem AP. Dental and Periodontal Health in Children with Hemophilia. J Coagul Disord 2009; (01) 7-10
  • 17 Evangelista LM, Lima CC, Idalino RC, Lima MD, Moura LF. Oral health in children and adolescents with haemophilia. Haemophilia 2015; 21 (06) 778-783
  • 18 Kabil N, ElAlfy MS, Metwalli N, Metwalli N. Evaluation of the oral health situation of a group of Egyptian haemophilic children and their re-evaluation following an oral hygiene and diet education programme. Haemophilia 2007; 13 (03) 287-292
  • 19 Othman NA, Sockalingam SN, Mahyuddin A. Oral health status in children and adolescents with haemophilia. Haemophilia 2015; 21 (05) 605-611
  • 20 Salem K, Eshghi P. Dental health and oral health-related quality of life in children with congenital bleeding disorders. Haemophilia 2013; 19 (01) 65-70
  • 21 Rajantie H, Alapulli H, Mäkipernaa A, Ranta S. Oral health care in children with haemophilia in Helsinki, Finland. Eur Arch Paediatr Dent 2013; 14 (05) 339-343
  • 22 Sonbol H, Pelargidou M, Lucas VS, Gelbier MJ, Mason C, Roberts GJ. Dental health indices and caries-related microflora in children with severe haemophilia. Haemophilia 2001; 7 (05) 468-474
  • 23 Gaddam KR, Nuvvula S, Nirmala S, Kamatham R. Oral health status among 6- to 12-year-old haemophilic children—an educational intervention study. Haemophilia 2014; 20 (04) e338-e341
  • 24 Azhar S, Yazdanie N, Muhammad N. Periodontal status and IOTN interventions among young hemophiliacs. Haemophilia 2006; 12 (04) 401-404
  • 25 Zaliuniene R, Aleksejuniene J, Peciuliene V, Brukiene V. Dental health and disease in patients with haemophilia—a case-control study. Haemophilia 2014; 20 (03) e194-e198
  • 26 Makarem A, Talebi M, Mazhari F, Kiyanosh N. Evaluation of oral and dental health status of Khorasan province hemophilic patients in 2004. J Mashhad Dent Sch 2008; 32: 161-168
  • 27 Ziebolz D, Stühmer C, Hornecker E, Zapf A, Mausberg RF, Chenot JF. Oral health in adult patients with congenital coagulation disorders—a case control study. Haemophilia 2011; 17 (03) 527-531
  • 28 Dimaisip-Nabuab J, Duijster D, Benzian H. et al. Nutritional status, dental caries and tooth eruption in children: a longitudinal study in Cambodia, Indonesia and Lao PDR. BMC Pediatr 2018; 18 (01) 300
  • 29 El Batawi HY, Fakhruddin KS. Impact of preventive care orientation on caries status among preschool children. Eur J Dent 2017; 11 (04) 475-479
  • 30 Alshahrani NF, Alshahrani ANA, Alahmari MA, Almanie AM, Alosbi AM, Togoo RA. First dental visit: age, reason, and experiences of Saudi children. Eur J Dent 2018; 12 (04) 579-584
  • 31 de Araújo Nobre MA, Sezinando AM, Fernandes IC, Araújo AC. Influence of smoking habits on the prevalence of dental caries: a register-based cohort study. Eur J Dent 2021; 15 (04) 714-719
  • 32 Nazir MA, Almas K. Awareness about the effects of tobacco consumption on oral health and the possibility of smoking behavior among male Saudi schoolchildren. Eur J Dent 2017; 11 (01) 29-35
  • 33 Díaz-Garrido N, Lozano C, Giacaman RA. Frequency of sucrose exposure on the cariogenicity of a biofilm-caries model. Eur J Dent 2016; 10 (03) 345-350
  • 34 Bokhari SAH, Almumtin K, Alhashiem WM, Albandar DY, Alyahya ZN, Alsaad E. Dental caries and associated risk indicators among married Saudi Women. Eur J Dent 2021
  • 35 Czajkowska S, Rupa-Matysek J, Gil L, Surdacka A. Practical recommendations for treatment of dental patients with congenital bleeding disorders during the Covid-19 Pandemic: a narrative review. Int J Environ Res Public Health 2020; 17 (19) 7245