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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2022; 43(03): 318-321
DOI: 10.1055/s-0042-1743125
Case Report with Review of Literature

A Rare Case of Life-Threatening Extensive Mucocutaneous Adverse Reaction Induced by Docetaxel in a Breast Cancer Patient: Toxic Epidermal Necrolysis, a Case Report with Review of Literature

Shiv Prasad Shrivastava
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Aditya Elhence
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Prutha Jinwala
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Shashank Bansal
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Prakash Chitalkar
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Shweta Bhatnagar
2   Department of Radiology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Rajesh Patidar
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
,
Vikas Asati
1   Department of Medical Oncology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
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Abstract

Fever and extensive necrosis with 30% or more epidermal involvement along with mucous membrane is known as toxic epidermal necrolysis (TEN). It is a life-threatening mucocutaneous disease and is usually drug induced. We report a rare case of docetaxel-induced TEN. A patient with metastatic breast carcinoma received single agent docetaxel and developed severe skin and mucous membrane reaction involving more than 30% of the skin, and managed conservatively in intensive care unit but she succumbed to her illness. Although common toxicities reported with docetaxel include alopecia, nail damage, myelosuppression, and erythema multiforme major, TEN after docetaxel is very rare and can be a life-threatening complication as in our case.

Keywords

docetaxel - toxic epidermal necrolysis - breast cancer - case report

Ethics

The authors certify that they have obtained an Ethics committee approval for publication (ECR/748/Inst/MP2015-EE/18, dated: 22 October 2021) from the institutional ethics committee of Sri Aurobindo Institute of Medical Sciences.




Publication History

Article published online:
28 June 2022

© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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