CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2022; 43(02): 139-143
DOI: 10.1055/s-0042-1742616
Case Report with Review of Literature

Megestrol Acetate in the Treatment of Post COVID-19 Fatigue in a Patient of Advanced Cancer: A Case Report and Mini Review of Literature

Chaitanya R Patil
1   Department of Pain and Palliative care, Kolhapur Cancer Center, Kolhapur, Maharashtra, India
Nilesh A Dhamne
2   Department of Medical Oncology, Kolhapur Cancer Center, Kolhapur, Maharashtra, India
Prasad K Tanawade
3   Department of Radiation Oncology, Kolhapur Cancer Center, Kolhapur, Maharashtra, India
Namrata B Mestri
4   Department of Pathology, DY Patil Medical College, Kolhapur, Maharashtra, India
› Author Affiliations


Megestrol acetate is one of the pharmacological agents used for cancer-associated fatigue. To date, there are no studies on its use in the treatment of post-COVID-19 (coronavirus disease 2019) fatigue. So, we report a case of metastatic carcinoma lung with a partial response with three cycles of palliative chemotherapy. He was contracted with mild COVID-19 infection post three cycles of his chemotherapy. Post this episode, fatigue was his main and most troublesome symptom. After a thorough clinical history, physical examination, and investigations, type 2 post-COVID-19 syndrome was diagnosed. After explaining the risks and benefits, we started the patient on low-dose megestrol acetate (160 mg/d per oral) with low to moderate benefits. However, upon increasing the dose to 480 mg/d, the benefit on the subjective quality of life was significant. Studies with a larger sample and randomized controlled trials have to be conducted to substantiate the hypothesis and actual effect of megestrol acetate in the treatment of post-COVID-19 fatigue.

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Publication History

Article published online:
14 April 2022

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