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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2023; 58(01): 141-148
DOI: 10.1055/s-0042-1742603
Artigo Original
Oncologia

Outcomes of Extended Curettage with and without Bone Allograft for Grade II Giant Cell Tumors around the Knee. A Retrospective Comparative Study

Article in several languages: português | English
Badaruddin Sahito 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
,
Sheikh Muhammad Ebad Ali 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
,
Bushra Majid 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
,
Muhammad Soughat Katto 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
,
Asif Jatoi 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
,
Syed Jahanzeb 
1   Department of Orthopedics, Dr Ruth KM Pfau Civil Hospital Karachi, Paquistão
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Abstract

Objective This is the first study to establish the utility of extended curettage with or without bone allograft for Grade II giant cell tumors GCTs around the knee joint with the aim of exploring postoperative functional outcomes.

Methods We retrospectively reviewed 25 cases of Campanacci grade II GCTs undergoing extended curettage between January 2014 and December 2019. The participants were divided into two groups: one group of 12 patients underwent extended curettage with bone allograft and bone cement, while the other group of 13 patients underwent extended curettage with bone cement only. Quality of life was assessed by the Revised Musculoskeletal Tumor Society Score and by the Knee score of the Knee Society; recurrence and complications were assessed for each cohort at the last follow-up. The Fisher test and two-sample t-tests were used to compare the categorical and continuous outcomes, respectively.

Results The mean age was 28.09 (7.44) years old, with 10 (40%) males and 15 females (60%). The distal femur and the proximal tibia were involved in 13 (52%) and in 12 (48%) patients, respectively. There was no significant difference in the musculoskeletal tumor society score (25.75 versus 27.41; p = 0.178), in the knee society score (78.67 versus 81.46; p = 0.33), recurrence (0 versus 0%; p = 1), and complications (25 versus 7.69%; p = 0.21).

Conclusions Extended curettage with or without bone allograft have similar functional outcomes for the knee without any major difference in the incidence of recurrence and of complications for Grade II GCTs. However, surgical convenience and cost-effectiveness might favor the bone cement only, while long-term osteoarthritis prevention needs to be investigated to favor bone allograft.

Keywords

giant cell tumors - bone grafting - bone cementing - extended curettage - knee/surgery

Ethics Approval

The study was approved by Human Subject Review Board.


Contributions of the Authors

Sahito B. and Ali S. M. E. conceived the study and performed data collection and critical revision. Majid B., Katto S. A., Jatoi A. and Jahanzeb S. performed designing, data interpretation and drafting. All the authors approved the final draft and stand accountable for the validity of the data.


Financial Support

There was no financial support from any public, commercial, or non-profit sources.


Work developed at Department of Orthopaedics Dr Ruth KM Pfau, Civil Hospital Karachi, Pakistan.




Publication History

Received: 12 August 2021

Accepted: 22 November 2021

Article published online:
25 April 2022

© 2022. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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