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CC BY-NC-ND 4.0 · Yearb Med Inform 2022; 31(01): 161-164
DOI: 10.1055/s-0042-1742530
Section 4: Clinical Research Informatics
Synopsis

Clinical Research Informatics

Christel Daniel
1   Information Technology Department, AP-HP, Paris, France
2   Sorbonne Université, Université Sorbonne Paris Nord, INSERM, LIMICS, Paris, France
,
Xavier Tannier
2   Sorbonne Université, Université Sorbonne Paris Nord, INSERM, LIMICS, Paris, France
,
Dipak Kalra
3   The University of Gent, Gent, Belgium
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Summary

Objectives: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2021.

Method: Using PubMed, we did a bibliographic search using a combination of MeSH descriptors and free-text terms on CRI, followed by a double-blind review in order to select a list of candidate best papers to be peer-reviewed by external reviewers. After peer-review ranking, three section editors met for a consensus meeting and the editorial team was organized to finally conclude on the selected three best papers.

Results: Among the 1,096 papers (published in 2021) returned by the search and in the scope of the various areas of CRI, the full review process selected three best papers. The first best paper describes an operational and scalable framework for generating EHR datasets based on a detailed clinical model with an application in the domain of the COVID-19 pandemics. The authors of the second best paper present a secure and scalable platform for the preprocessing of biomedical data for deep data-driven health management applied for the detection of pre-symptomatic COVID-19 cases and for biological characterization of insulin-resistance heterogeneity. The third best paper provides a contribution to the integration of care and research activities with the REDCap Clinical Data and Interoperability sServices (CDIS) module improving the accuracy and efficiency of data collection.

Conclusions: The COVID-19 pandemic is still significantly stimulating research efforts in the CRI field to improve the process deeply and widely for conducting real-world studies as well as for optimizing clinical trials, the duration and cost of which are constantly increasing. The current health crisis highlights the need for healthcare institutions to continue the development and deployment of Big Data spaces, to strengthen their expertise in data science and to implement efficient data quality evaluation and improvement programs.

Keywords

Clinical Trials as Topic - Observational Studies as Topic - Real-world Data - Real-world Evidence Generation - Phenotyping

1 Proposal for a Regulation of the European Parliament and of The Council Laying Down Harmonised Rules on Artificial Intelligence (Artificial Intelligence Act) And Amending Certain Union Legislative Acts https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A52021PC0206


Section Editors for the IMIA Yearbook Section on Clinical Research Informatics




Publication History

Article published online:
04 December 2022

© 2022. IMIA and Thieme. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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