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CC BY 4.0 · Rev Bras Ginecol Obstet 2022; 44(04): 409-424
DOI: 10.1055/s-0042-1742409
Review Article
Review

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Deficiência e insuficiência de vitamina D em mulheres na idade reprodutiva: Uma revisão sistemática e meta-análise

Autor*innen

  • Rosa Camila Lucchetta 

    1   Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual de São Paulo, São Paulo, SP, Brazil

  • Isabele Held Lemos 

    1   Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual de São Paulo, São Paulo, SP, Brazil

  • Ana Luísa Rodriguez Gini 

    1   Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual de São Paulo, São Paulo, SP, Brazil

  • Sophia de Andrade Cavicchioli 

    2   Universidade de Araraquara, Araraquara, São Paulo, SP, Brazil

  • Marcela Forgerini 

    1   Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual de São Paulo, São Paulo, SP, Brazil

  • Fabiana Rossi Varallo 

    3   Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil

  • Mariane Nunes de Nadai 

    4   Department of Dentistry, Pediatric Dentistry and Public Health, Bauru School of Dentistry, Universidade de São Paulo, Bauru, SP, Brazil

  • Fernando Fernandez-Llimos 

    5   Department of Drug Sciences, Laboratory of Pharmacology, Faculty of Pharmacy, Universidade do Porto, Porto, Portugal

  • Patricia de Carvalho Mastroianni 

    1   Department of Drugs and Medicines, School of Pharmaceutical Sciences, Universidade Estadual de São Paulo, São Paulo, SP, Brazil

Funding/Acknowledgments This study was funded by the Ministry of Science, Technology, Innovation and Communications, Ministry of Health of Brazil – MoH, and the National Council for Scientific and Technological Development – CNPq (n. 26/2019, process 4426122019-2). Additionally, this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) – Finance Code 001, and the São Paulo Research Foundation (FAPESP) [grant number 2018/07501-9].
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Abstract

Objective To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil.

Methods A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies.

Results Our review identified 31 studies, comprising 4,006 participants. All the studies had at least one weakness, mainly due to the use of convenience sampling and small sample size. The overall prevalence of vitamin D deficiency, insufficiency, and both deficiency and insufficiency were 35% (confidence interval, 95%CI: 34–37%), 42% (95%CI: 41–44%), and 72% (95%CI: 71–74%), respectively.

Conclusion Although the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems.

Resumo

Objetivo Estimar a prevalência de níveis inadequados de vitamina D e seus fatores associados para mulheres em idade fértil no Brasil.

Métodos Uma revisão sistemática foi realizada (última atualização em maio de 2020). As meta-análises foram realizadas usando o inverso da variância para o modelo fixo com cálculo de proporção sumarizada por transformação arco-seno duplo de Freeman-Tukey. A qualidade metodológica e de reporte foi avaliada usando a ferramenta do Joanna Briggs Institute para estudos de prevalência.

Resultados Nossa revisão identificou 31 estudos, compreendendo 4.006 participantes. Todos os estudos apresentaram pelo menos uma limitação, principalmente devido ao uso de amostra de conveniência e tamanho amostral pequeno. As prevalências gerais de deficiência, insuficiência e deficiência de vitamina D foram 35% (intervalo de confiança, IC 95%: 34–37%), 42% (IC 95%: 41–44%) e 72% (IC 95%: 71–74%), respectivamente.

Conclusão Embora a magnitude da prevalência de níveis inadequados de vitamina D seja incerta, a evidência sugere que presença de deficiência ou insuficiência de vitamina D em mulheres em idade reprodutiva pode causar problemas moderados a graves.

Keywords

cholecalciferol - vitamin D deficiency - nutritional epidemiology - maternal nutrition - women's health

Palavras-chave

colecalciferol - deficiência de vitamina D - epidemiologia nutricional - nutrição materna - saúde da mulher

Contributions

Lucchetta RC: Conceptualization, Methodology, Writing, Investigation, Visualization, Supervision, Validation; Lemos IH: Writing- Reviewing and Editing, and Investigation; Gini ALR: Writing- Reviewing and Editing, and Investigation; Cavicchioli SA: Writing- Reviewing and Editing, and Investigation; Forgerini M: Visualization, Writing- Reviewing and Editing; Varallo FR: Visualization, Writing- Reviewing and Editing; de Nadai MN: Visualization, Writing- Reviewing and Editing; Fernando Fernandez-Llimós: Visualization, Writing- Reviewing and Editing; Mastroianni P: Conceptualization, Visualization, Validation, Writing- Reviewing and Editing, Project administration.


Supplementary Material



Publikationsverlauf

Eingereicht: 20. April 2021

Angenommen: 03. November 2021

Artikel online veröffentlicht:
24. Februar 2022

© 2022. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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