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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2022; 43(02): 216-222
DOI: 10.1055/s-0042-1742334
Case Report with Review of Literature

Unilateral Interstitial Lung Disease with Contralateral Effusion: Unusual Case Report of Dasatinib Toxicity

Maheema Bhaskar
1   Department of Pulmonary Medicine, Tata Memorial hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Pavankumar Biraris
1   Department of Pulmonary Medicine, Tata Memorial hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Owais Tisekar
1   Department of Pulmonary Medicine, Tata Memorial hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Rajiv Kumar Kaushal
2   Department of Pathology, Tata Memorial Hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Amit Janu
3   Department of Radiology, Tata Memorial hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Sandeep Tandon
1   Department of Pulmonary Medicine, Tata Memorial hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India
› Institutsangaben Funding None.
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Abstract

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used in chronic myelogenous leukemia (CML). While pleural effusion due to Dasatinib is well described in the literature, interstitial lung disease (ILD) caused by it is rare. A 60-year-old gentleman was on treatment with 100 mg of tablet Dasatinib per day for chronic myeloid leukemia. He presented to the outpatient department with history of progressive breathlessness over 2 months. High-resolution computerized tomography (HRCT) thorax revealed mild right-sided effusion and non-specific interstitial pneumonia (NSIP) pattern of ILD in the left lower lobe. Thoracocentesis of the right-sided pleural effusion showed exudative and lymphocytic rich pleural effusion. The effusion was negative for malignant cells or infection. Biopsy of the left lower lobe was consistent with the diagnosis of ILD. He was started on prednisolone which was gradually tapered and stopped. At 3 months, there was a complete resolution of the ILD and pleural effusion. Clinicians need to be aware about the pleuroparenchymal toxicities of Dasatinib. Early diagnosis and treatment with steroids can lead to complete resolution of the signs and symptoms.

Keywords

Dasatinib - interstitial lung disease - prednisolone - chronic myelogenous leukemia

Declaration of Patient Consent

Patient consent is taken at the time of patient's registration at the Hospital for use of their anonymized data for research purpose.


Sources of Support

None.




Publikationsverlauf

Artikel online veröffentlicht:
15. Februar 2022

© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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