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CC BY-NC-ND 4.0 · Journal of Coloproctology 2022; 42(02): 131-139
DOI: 10.1055/s-0042-1742310
Original Article

Surgical Roles in the Management of Metachronus Para-aortic Lymph Node Recurrence and Synchronous Para-aortic Lymph Node Metastasis in Colorectal Cancer Patients

Osama Abd-Elaziz
1   Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Ramadan M. Ali
1   Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Mohamed Farouk Amin
1   Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Ahmed M. Fahmy
2   Department of Anesthesia and Intensive Care, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Shereen Elshorbagy
3   Department of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Doaa Mandour
4   Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Rehab Hemeda
4   Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Ola A. Harb 
5   Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Amr Samir
6   Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Elsayed I. El-Hendawy
1   Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
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Abstract

Background The relative rarity of synchronous para-aortic lymph node (PALN) metastasis (SPM) and metachronous PALN recurrence (MPR) in colorectal carcinoma (CRC) patients leads to a limited number of studies on patient management, and no treatment guidelines have been established to date.

Objective To assess the prognostic, predictive roles, and long-term outcomes of different management strategies for isolated MPR and SPM in CRC patients to establish the best one.

Materials and Methods We included 35 CRC patients with isolated MPR and 25 patients with isolated SPM who underwent curative R0 resection. We performed PALN dissection (PALND) in 15 cases in MPR group and in 10 cases in the SPM group; all remaining patients in both groups underwent chemoradiotherapy (CRT) without further surgical intervention. During the study period of about 5 years, we compared the patients who underwent PALND and those who underwent CRT.

Results The overall survival and recurrence-free survival rates were significantly longer in patients who underwent PALND (p = 0.049 and 0.036 respectively).

Conclusions We showed that PALND in cases of CRC patients with SPM and MPR previously submitted to R0 resection was associated with favorable outcomes and better patient survival.

Keywords

colorectal cancer - metachronous para-aortic lymph node recurrence - synchronous para-aortic lymph node metastasis - surgery


Publikationsverlauf

Eingereicht: 24. Juli 2021

Angenommen: 25. Oktober 2021

Artikel online veröffentlicht:
31. Januar 2022

© 2022. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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