Klin Monbl Augenheilkd 2017; 234(04): 455-456
DOI: 10.1055/s-0042-123148
Der interessante Fall
Georg Thieme Verlag KG Stuttgart · New York

Osteo-Odonto-Keratoprosthesis in Severe Ocular Graft versus Host Disease

Osteo-Odonto-Keratoprothese bei schwerer okulärer Graft-versus-Host-Reaktion
K. Plattner
1   Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
,
D. Goldblum
1   Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
,
J. Halter
2   Department of Hematology, University Hospital Basel, University of Basel, Basel, Switzerland
,
C. Kunz
3   Department of Oral and Maxillofacial Surgery, University Hospital Basel, University of Basel, Basel, Switzerland
,
R. Koeppl
4   Department of Otorhinolaryngology, University Hospital Basel, University of Basel, Basel, Switzerland
,
N. Gerber-Hollbach
1   Department of Ophthalmology, University Hospital Basel, University of Basel, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
22 March 2017 (online)

Background

Ocular graft versus host disease (GvHD) is an immunological complication of allogenic hematopoietic stem cell transplantation (AHSCT), which may lead to vision threatening conditions as corneal ulcers and perforations [1]. Although therapeutic options in patients with end-stage ocular disease range from intensive topical and systemic treatment, amniotic membrane, conjunctival or mucosal flaps to keratoplasty, often corneal scaring cannot be prevented. In most severe cases keratoprosthesis is the only option for visual rehabilitation [1], [2]. We present a case with osteo-odonto-keratoprosthesis (OOKP) as the last treatment option for bilateral corneal blindness and 6 months follow up in a patient with severe ocular GvHD.

 
  • References

  • 1 Nassar A, Tabbara KF, Aljurf M. Ocular manifestations of graft-versus-host disease. Saudi J Ophthalmol 2013; 27: 215-222
  • 2 Avadhanam VS, Smith HE, Liu C. Keratoprostheses for corneal blindness: a review of contemporary devices. Clin Ophthalmol 2015; 16: 697-720
  • 3 Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol 2013; 58: 233-251
  • 4 Tan A, Tam DT, Tan XW. et al. Osteo-odonto-keratoprosthesis: systematic review of surgical outcomes and complication rates. Ocul Surf 2012; 10: 15-25
  • 5 Falcinelli G, Falsini B, Taloni M. et al. Modified osteo-odonto-keratoprosthesis for treatment of corneal blindness: long-term anatomical and functional outcomes in 181 cases. Arch Ophthalmol 2005; 123: 1319-1329