Exercise as an Effective Transgenerational Strategy to Overcome Metabolic Syndrome in the Future Generation: Are We There?

Ramires Alsamir Tibana; Octávio Luiz Franco; Rinaldo Wellerson Pereira; James Navalta; Jonato Prestes

doi:10.1055/s-0042-120538

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2017; 125(06): 347-352
DOI: 10.1055/s-0042-120538

Mini-Review

Exercise as an Effective Transgenerational Strategy to Overcome Metabolic Syndrome in the Future Generation: Are We There?

Ramires Alsamir Tibana

¹Universidade Católica de Brasília. Programa de Pós-Graduação Stricto Sensu em Educação Física. Brasília, DF, Brasil

,

Octávio Luiz Franco

¹Universidade Católica de Brasília. Programa de Pós-Graduação Stricto Sensu em Educação Física. Brasília, DF, Brasil

²Centro de Análises Proteômicas e Bioquímicas. Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brazil

,

Rinaldo Wellerson Pereira

¹Universidade Católica de Brasília. Programa de Pós-Graduação Stricto Sensu em Educação Física. Brasília, DF, Brasil

²Centro de Análises Proteômicas e Bioquímicas. Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brazil

,

James Navalta

³Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, USA

,

Jonato Prestes

¹Universidade Católica de Brasília. Programa de Pós-Graduação Stricto Sensu em Educação Física. Brasília, DF, Brasil

› Author Affiliations

Abstract

Metabolic syndrome (MetS) consist in a combination of cardiovascular risk factors including elevated blood pressure, dyslipidemia, insulin resistance, hyperglycemia and abdominal obesity. Exercise performed before, during and after pregnancy can exert positive effects to counteract MetS risk factors. Here this review aims to analyze the effects of exercise performed before (fathers and mothers) and after periconception (mothers) by using experimental models and its effects on MetS risk factors in offspring. All selected studies investigated the effects of aerobic exercise before, during and after periconception on MetS risk factors in offspring, while no studies utilizing resistance exercise were found. Exercise performed before, and after periconception exerted preventive effects in the offspring, with regards to MetS risk factors. However, more studies focusing on the dose-response of exercise before, and after periconception may reveal interesting results on MetS risk factor in offspring. Thus, the prevention from chronic degenerative diseases can be improved by mother exercise and might be associated with epigenetic mechanisms, such as DNA methylation, hPTMs (histone post translational modifications), non-coding RNAs (ex: MicroRNAs) which results phenotypic modifications by individual genome reprograming. Otherwise, results from paternal exercise are inconclusive at this time.

Key words

cardiovascular risk factors - exercise transgenerational effects - physical training - epigenetics

Full Text

References

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