Int J Sports Med 2017; 38(02): 118-124
DOI: 10.1055/s-0042-119204
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Acute and Long-term Responses to Different Rest Intervals in Low-load Resistance Training

Julius Etienne Fink
1   Graduate Schools of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan
Brad Jon Schoenfeld
2   Department of Health Sciences, Lehman College, Bronx, United States
Naoki Kikuchi
3   Nihon Taiiku Daigaku, Training Science, Setagaya-ku, Japan
Koichi Nakazato
4   Exercise Physiology, Nippon Sport Science University, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

accepted after revision 04 October 2016

Publication Date:
16 December 2016 (online)


We investigated the effects of low-load resistance training to failure performed with different rest intervals on acute hormonal responses and long-term muscle and strength gains. In the acute study, 14 participants were assigned to either a short rest (S, 30 s) or long rest (L, 150 s) protocol at 40% one-repetition maximum. Blood samples were taken before and after the workout. Both groups showed significant (p<0.05) increases in growth hormone and insulin-like growth factor 1 immediately post-workout. In the longitudinal study, the same protocol as in the acute study was performed 2 times per week for 8 weeks by 21 volunteers. Both groups showed significant increases in triceps (S: 9.8±8.8%, L: 10.6±9.6%, p<0.05) and thigh (S: 5.7±4.7%, L: 8.3±6.4%, p<0.05) cross-sectional area. One-repetition maximum also significantly increased for the bench press (S: 9.9±6.9%, L: 6.5±5.8%, p<0.05) and squat (S: 5.2±6.7%, L: 5.4±3.5%, p<0.05). In conclusion, our results suggest that acute hormonal responses, as well as chronic changes in muscle hypertrophy and strength in low-load training to failure are independent of the rest interval length.

  • References

  • 1 Ahtiainen JP, Pakarinen A, Alen M, Kraemer WJ, Häkkinen K. Short vs. long rest period between the sets in hypertrophic resistance training: influence on muscle strength, size, and hormonal adaptations in trained men. J Strength Cond Res 2005; 19: 572-582
  • 2 Bosco C, Colli R, Bonomi R, von Duvillard SP, Viru A. Monitoring strength training: neuromuscular and hormonal profile. Med Sci Sports Exerc 2000; 32: 202-208
  • 3 Burd NA, West DWD, Staples AW, Atherton PJ, Baker JM, Moore DR, Holwerda AM, Parise G, Rennie MJ, Baker SK. Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PloS one 2010; 5: e12033
  • 4 Buresh R, Berg K, French J. The effect of resistive exercise rest interval on hormonal response, strength, and hypertrophy with training. J Strength Cond Res 2009; 23: 62-71
  • 5 Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol 2002; 88: 50-60
  • 6 Carpinelli RN. The size principle and a critical analysis of the unsubstantiated heavier-is-better recommendation for resistance training. J Exerc Sci Fit 2008; 6: 67-86
  • 7 Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd edn. Hillsdale, New Jersey: L. In: Erlbaum; 1988
  • 8 Faul F, Erdfelder E, Lang A-G, Buchner A. G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-191
  • 9 Fink J, Kikuchi N, Yoshida S, Terada K, Nakazato K. Impact of high versus low fixed loads and non-linear training loads on muscle hypertrophy, strength and force development. SpringerPlus 2016; 5: 698
  • 10 Goto K, Ishii N, Kizuka T, Takamatsu K. The impact of metabolic stress on hormonal responses and muscular adaptations. Med Sci Sports Exerc 2005; 37: 955-963
  • 11 Goto K, Nagasawa M, Yanagisawa O, Kizuka T, Ishii N, Takamatsu K. Muscular adaptations to combinations of high-and low-intensity resistance exercises. J Strength Cond Res 2004; 18: 730-737
  • 12 Haff GG, Triplett NT. Essentials of Strength Training and Conditioning 4th Edition: Human kinetics. 2015
  • 13 Harriss D, Atkinson G. Ethical standards in sport and exercise science research: 2016 update. Int J Sports Med 2015; 36: 1121-1124
  • 14 Jenkins ND, Housh TJ, Buckner SL, Bergstrom HC, Cochrane KC, Hill EC, Smith CM, Schmidt RJ, Johnson GO, Cramer JT. Neuromuscular adaptations after 2-and 4-weeks of 80% versus 30% 1RM resistance training to failure. J Strength Cond Res 2015; DOI: 10.1519/JSC.0000000000001308.
  • 15 Kraemer W, Noble B, Clark M, Culver B. Physiologic responses to heavy-resistance exercise with very short rest periods. Int J Sports Med 1987; 8: 247-252
  • 16 Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R, Frykman P, McCurry D, Fleck SJ. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69: 1442-1450
  • 17 Krieger JW. Single versus multiple sets of resistance exercise: a meta-regression. J Strength Cond Res 2009; 23: 1890-1901
  • 18 Krieger JW. Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis. J Strength Cond Res 2010; 24: 1150-1159
  • 19 MacDougall J, Sale D, Alway S, Sutton J. Muscle fiber number in biceps brachii in bodybuilders and control subjects. J Appl Physiol 1984; 57: 1399-1403
  • 20 McCall G, Byrnes W, Dickinson A, Pattany P, Fleck S. Muscle fiber hypertrophy, hyperplasia, and capillary density in college men after resistance training. J Appl Physiol 1996; 81: 2004-2012
  • 21 McKendry J, Pérez-López A, McLeod M, Luo D, Dent JR, Smeuninx B, Yu J, Taylor AE, Philp A, Breen L. Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signalling in young males. Exp Physiol 2016; 101: 866-882
  • 22 Mitchell CJ, Churchward-Venne TA, West DW, Burd NA, Breen L, Baker SK, Phillips SM. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol 2012; 113: 71-77
  • 23 Ogasawara R, Loenneke JP, Thiebaud RS, Abe T. Low-load bench press training to fatigue results in muscle hypertrophy similar to high-load bench press training. Int J. Clin Med 2013; 4: 114
  • 24 Popov DV, Swirkun DV, Netreba AI, Tarasova OS, Prostova AB, Larina IM, Borovik AS, Vinogradova OL. Hormonal adaptation determines the increase in muscle mass and strength during low-intensity strength training without relaxation. Human Physiol 2006; 32: 609-614
  • 25 Rønnestad BR, Nygaard H, Raastad T. Physiological elevation of endogenous hormones results in superior strength training adaptation. Eur J Appl Physiol 2011; 111: 2249-2259
  • 26 Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res 2010; 24: 2857-2872
  • 27 Schoenfeld BJ. Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training. Sports Med 2013; 43: 179-194
  • 28 Schoenfeld BJ, Peterson MD, Ogborn D, Contreras B, Sonmez GT. Effects of Low-Versus High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men. J Strength Cond Res 2015; 29: 2954-2963
  • 29 Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnaiter JA, Bond-Williams KE, Carter AS, Ross CL. Longer inter-set rest periods enhance muscle strength and hypertrophy in resistance-trained men. J Strength Cond Res 2015; 30: 1805-1812
  • 30 Schoenfeld BJ, Wilson JM, Lowery RP, Krieger JW. Muscular adaptations in low-versus high-load resistance training: A meta-analysis. Eur J Sport Sci 2016; 16: 1-10
  • 31 Schuenke MD, Herman JR, Gliders RM, Hagerman FC, Hikida RS, Rana SR, Ragg KE, Staron RS. Early-phase muscular adaptations in response to slow-speed versus traditional resistance-training regimens. Eur J Appl Physiol 2012; 112: 3585-3595
  • 32 Villanueva MG, Lane CJ, Schroeder ET. Short rest interval lengths between sets optimally enhance body composition and performance with 8 weeks of strength resistance training in older men. Eur J Appl Physiol 2015; 115: 295-308
  • 33 West DWD, Burd NA, Tang JE, Moore DR, Staples AW, Holwerda AM, Baker SK, Phillips SM. Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol 2010; 108: 60-67
  • 34 West DWD, Kujbida GW, Moore DR, Atherton P, Burd NA, Padzik JP, De Lisio M, Tang JE, Parise G, Rennie MJ. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. J Physiol 2009; 587: 5239-5247
  • 35 Willardson JM, Burkett LN. The effect of rest interval length on bench press performance with heavy vs. light loads. J Strength Cond Res 2006; 20: 396-399
  • 36 Willardson JM, Burkett LN. The effect of different rest intervals between sets on volume components and strength gains. J Strength Cond Res 2008; 22: 146-152