Int J Sports Med 2017; 38(05): 402-406
DOI: 10.1055/s-0042-118649
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts

Naoki Kikuchi
1  Department of Training Science, Nippon Sport Science University, Tokyo, Japan
,
Hirofumi Zempo
2  Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan
3  Research fellow of the Japan Society for the Promotion of Science, Tokyo, Japan
,
Noriyuki Fuku
2  Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan
,
Haruka Murakami
4  Health Promotion and Exercise Program, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan
,
Mikako Sakamaki-Sunaga
5  Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan
,
Takanobu Okamoto
5  Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan
,
Koichi Nakazato
5  Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan
,
Motohiko Miyachi
4  Health Promotion and Exercise Program, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan
› Author Affiliations
Further Information

Publication History



accepted after revision 27 September 2016

Publication Date:
16 March 2017 (eFirst)

Abstract

α-Actinin-3 (ACTN3) R577X polymorphism is associated with muscular strength and power. This study was performed to investigate the association between ACTN3 R577X polymorphisms and flexibility as another component of fitness in 2 cohorts. Cohort 1 consisted of 208 men and 568 women (ages 23–88), while Cohort 2 consisted of 529 men and 728 women (ages 23–87). All participants were recruited from the Tokyo metropolitan area and underwent a battery of tests to assess their grip strength and sit-and-reach flexibility. Genotyping results were analyzed for ACTN3 (rs1815739) polymorphism using the TaqMan approach. In Cohort 1, sit-and-reach in the RR genotype (35.3±0.7 cm) was significantly lower than those in the RX and XX genotypes (37.2±0.3 cm) even after adjusting for sex, age, and exercise habit as covariates (P<0.01). In Cohort 2, sit-and-reach tended to be lower in RR (38.1±0.6 cm) than in RX and XX (39.1±0.3 cm), but the differences were not significant (P=0.114). Analysis in pooled subjects indicated that RR was associated with significantly lower flexibility than RX and XX (P=0.009). The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.