Int J Sports Med 2017; 38(1): 76-80
DOI: 10.1055/s-0042-117113
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance

N. Kikuchi
1   Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan
,
N. Fuku
2   Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan
,
R. Matsumoto
3   Graduate School of Medicine, Gunma University, Maebashi-city, Japan
,
S. Matsumoto
1   Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan
,
H. Murakami
4   Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan
,
M. Miyachi
4   Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan
,
K. Nakazato
5   Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan
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Publikationsverlauf



accepted after revision 30. August 2016

Publikationsdatum:
03. November 2016 (online)

Abstract

The purpose of this study was to investigate the effects of the MCT1 T1470A polymorphism (rs1049434) on power-oriented performance and lactate concentration during or after cycling sprints in Japanese wrestlers. Participants (199 wrestlers and 649 controls) were genotyped for the MCT1 T1470A genotype (rs1049434) using the TaqMan® Assay. All wrestlers were international (n=77) or national (n=122) level athletes. Among them, 46 wrestlers performed 2 anaerobic performance tests, a 30-s Wingate Anaerobic test (WAnT) and a series of 10 maximal effort 10-s sprints on a cycle ergometer. Blood lactate levels were measured before, during, and after the tests. In the A-allele recessive model (AA vs. TA+TT), the frequency of the AA genotype was significantly higher in all wrestlers than in controls (p=0.037). Wrestlers with AA genotype had lower blood lactate concentrations than those with TA+TT genotype at 10 min after the WAnT and following the 5th and the final set of repeated cycling sprints (p<0.05). The AA genotype of the MCT1 T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s WAnT and during intermittent sprint tests in Japanese wrestlers.

Supplementary Material

 
  • References

  • 1 Ben-Zaken S, Eliakim A, Nemet D, Rabinovich M, Kassem E, Meckel Y. Differences in MCT1 A1470T polymorphism prevalence between runners and swimmers. Scand J Med Sci Sports 2015; 25: 365-371
  • 2 Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2006–2007 update. Med Sci Sports Exerc 2009; 41: 35-73
  • 3 Brooks GA. Intra- and extra-cellular lactate shuttles. Med Sci Sports Exerc 2000; 32: 790-799
  • 4 Chino K, Saito Y, Matsumoto S, Ikeda T, Yanagawa Y. Investigation of exercise intensity during a freestyle wrestling match. J Sports Med Phys Fitness 2015; 55: 290-296
  • 5 Cupeiro R, Benito PJ, Maffulli N, Calderon FJ, Gonzalez-Lamuno D. MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. J Sci Med Sport 2010; 13: 526-530
  • 6 Cupeiro R, Gonzalez-Lamuno D, Amigo T, Peinado AB, Ruiz JR, Ortega FB, Benito PJ. Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women. J Sci Med Sport 2012; 15: 541-547
  • 7 De Moor MH, Spector TD, Cherkas LF, Falchi M, Hottenga JJ, Boomsma DI, De Geus EJ. Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet 2007; 10: 812-820
  • 8 Dubouchaud H, Butterfield GE, Wolfel EE, Bergman BC, Brooks GA. Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. nur Am J Physiol 2000; 278: E571-E579
  • 9 Fedotovskaya ON, Mustafina LJ, Popov DV, Vinogradova OL, Ahmetov II. A common polymorphism of the MCT1 gene and athletic performance. Int J Sports Physiol Perform 2014; 9: 173-180
  • 10 Flohr JA, Womack CJ, Kovalcik PC. Comparison of capillary and venous blood lactate and glucose values during cycle ergometry. J Sports Med Phys Fitness 1996; 36: 261-264
  • 11 Garcia-Pallares J, Lopez-Gullon JM, Muriel X, Diaz A, Izquierdo M. Physical fitness factors to predict male Olympic wrestling performance. Eur J Appl Physiol 2011; 111: 1747-1758
  • 12 Gonzalez-Haro C, Soria M, Vicente J, Fanlo AJ, Sinues B, Escanero JF. Variants of the solute carrier SLC16A1 gene (MCT1) associated with metabolic responses during a long-graded test in road cyclists. J Strength Cond Res 2015; 29: 3494-3505
  • 13 Harriss DJ, Atkinson G. Ethical standards in sport and exercise science research: 2016 update. Int J Sports Med 2015; 36: 1121-1124
  • 14 Hubner-Wozniak E, Kosmol A, Lutoslawska G, Bem EZ. Anaerobic performance of arms and legs in male and female free style wrestlers. J Sci Med Sport 2004; 7: 473-480
  • 15 Karnincic H, Tocilj Z, Uljevic O, Erceg M. Lactate profile during greco-roman wrestling match. J Sports Sci Med 2009; 8: 17-19
  • 16 Kikuchi N, Min SK, Ueda D, Igawa S, Nakazato K. Higher frequency of the ACTN3 R allele+ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res 2012; 26: 3275-3280
  • 17 Kikuchi N, Ueda D, Min SK, Nakazato K, Igawa S. The ACTN3 XX genotype’s underrepresentation in Japanese elite wrestlers. Int J Sports Physiol Perform 2013; 8: 57-61
  • 18 Lean CB, Lee EJ. Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore. Drug Metab Pharmacokinet 2009; 24: 469-474
  • 19 Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW. Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. Muscle Nerve 2000; 23: 90-97
  • 20 Pilegaard H, Terzis G, Halestrap A, Juel C. Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle. Am J Physiol 1999; 276: E843-E848
  • 21 Pitsiladis Y, Wang G, Wolfarth B, Scott R, Fuku N, Mikami E, He Z, Fiuza-Luces C, Eynon N, Lucia A. Genomics of elite sporting performance: what little we know and necessary advances. Br J Sports Med 2013; 47: 550-555
  • 22 Sasaki S, Futagi Y, Kobayashi M, Ogura J, Iseki K. Functional characterization of 5-oxoproline transport via SLC16A1/MCT1. J Biol Chem 2015; 290: 2303-2311
  • 23 Sawczuk M, Banting LK, Cieszczyk P, Maciejewska-Karlowska A, Zarebska A, Leonska-Duniec A, Jastrzebski Z, Bishop DJ, Eynon N. MCT1 A1470T: a novel polymorphism for sprint performance?. J Sci Med Sport 2015; 18: 114-118
  • 24 Yoon J. Physiological profiles of elite senior wrestlers. Sports Med 2002; 32: 225-233