Pedunculated gastric neuroendocrine tumor: a case report

Background and study aims: Gastric neuroendocrine tumors (NETs) are rare lesions that develop from neuroendocrine cells. NETs are classified into 3 types based on the rate of mitosis and Ki-67 labeling index; the NET G1 type is synonymously referred to as carcinoid. Gastric NETs are usually discovered as submucosal tumors during upper gastrointestinal endoscopic examination. This study reports a rare case of pedunculated gastric NET. The lesion was found as a result of gastroendoscopy. The gastric lesion was a pedunculated polyp with a reddish head. We performed endoscopic submucosal dissection and an en-bloc resection of the gastric lesion. The resected specimen was evaluated histopathologically and diagnosed as a carcinoid (NET G1).

• References

• 1 Nikou GC, Angelopoulos TP. Current concepts on gastric carcinoid tumors. Gastroenterol Res Pract Epub 2012 Dec 17
• 2 Rindi G, Arnold R, Bosman FT et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Hruban R, et al., eds. WHO classification of tumours of the digestive system. Lyon: International Agency for Research on cancer (IARC); 2010
• 3 Tsushimi T, Mori H, Harada T et al. Laparoscopic and endoscopic cooperative surgery for duodenal neuroendocrine tumor (NET) G1: report of a case. Int. J. Surg Case Rep 2014; 5: 1021-1024
• 4 Ramage J, Davies A, Ardill J et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut 2005; 54 (Suppl. 04) iv1-16
• 5 Hirai M, Matsumoto K, Ueyama H et al. A case of neuroendocrine tumor G1 with unique histopathological growth progress. World J Gastrointest Endosc 2013; 5: 605-609
• 6 Ichikawa J, Tanabe S, Koizumi W et al. Endoscopic mucosal resection in the management of gastric carcinoid tumors. Endoscopy 2003; 35: 203-206
• 7 Sato Y. Clinical features and management of type 1 gastric carcinoids. Clin J Gastroenterol 2014; 7: 381-386
• 8 Delle Fave G, Kwekkeboom DJ, Van Cutsem E et al. ENETS Consensus guidelines for the management of patients with gastroduodenal neoplasms. Neuroendocrinology 2012; 95: 74-87
• 9 Fisher JK. Multiple sessile and pedunculated gastric carcinoids. Mo Med 1984; 81: 81-85
• 10 Bhatnagar S, Borg-Grech A. Gastric polyposis caused by multiple carcinoids and early carcinoma. J Clin Pathol 1995; 48: 589-591