Drug Res (Stuttg) 2017; 67(01): 5-12
DOI: 10.1055/s-0042-115015
Opinion Paper
© Georg Thieme Verlag KG Stuttgart · New York

Filling the Gap – Improving Awareness and Practice in Hyponatraemia and the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in the Older Patient: A European Consensus View

M. Wehling
1   Department of Clinical Pharmacology, Center for Geriatric Pharmacology in Mannheim
C. Ashton
2   South Warwickshire NHS Foundation Trust, Warwick, UK
E. Ekpo
3   Lewisham and Greenwich NHS Trust, London, UK
S. Gwynn
4   SG Market Access Ltd, Chichester, UK
M. Laville
5   Department of Nephrology, Lyon Sud University Hospital, Pierre Benite, France
K. Olsson
6   Lund University, Sweden
M. Spring
7   Kingston Hospital, NHS Foumdation Trust, Kingston, UK
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received 07. April 2016

accepted 09. August 2016

04. Oktober 2016 (online)


Introduction: Causes of hyponatraemia in older patients are multivariate and in the case of SIADH may often be drug induced. Diagnostic and treatment algorithms are unclear for this important age group.

Methods: The author group identified 6 broad themes for consensus and formulated 42 separate consensus statements within these 6 themes. Statements were then circulated to geriatricians, general practitioners and other doctors to test agreement at the European level.

Results: 64 responses were evaluated from around Europe. Agreement was achieved in 86% of the statements following amendment and redistribution of 6 of the statements. The survey and its feedback prompted the development of 13 recommendations related to the diagnosis and treatment of hyponatraemia including SIADH.

Conclusion: The series of 13 recommendations developed here is intended to increase clarity for clinicians managing older patients with hyponatraemia and SIADH. Surprisingly, despite the lack of clear guidelines or recommendations for this age group consensus levels for the author-based statements were high among the respondents.

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