Abstract
Introduction: We present a retrospective 2-year follow-up cohort of 103 men with testicular microlithiasis
(TML) and discuss patient compliance and the value of surveillance.
Methods: A retrospective analysis of patients examined with scrotal ultrasonography (US) in
the period from 2008 through 2010 was performed. A total of 103 men with TML were
diagnosed and offered US follow-up every 6 months for 2 years. They were retrospectively
analyzed regarding demographics and follow-up details, including the development of
any kind of malignancy until March 2015, using the Danish Electronic Pathology Registry.
Results: The prevalence of TML was 10.3%. Of the 103 men with TML, 23 (22.3%) had TML in the
left testicle, 38 (36.9%) in the right (p=0.002), and 42 (40.8%) had bilateral TML.
Patient compliance was low with 11.7% participating in all US follow-up examinations.
5 men presented risk factors (testicular atrophy (N=1) and previous testicular cancer
(N=4)), but no cases of testicular malignancy were found in the follow-up period.
Conclusion: The low patient compliance conflicts with the ESUR Scrotal Imaging Subcommittee guidelines
that recommend scrotal US follow-up annually for TML until the age of 55 years. The
fact that no cancers were found during follow-up using the pathology registry calls
the value of follow-up into question.
Key words
testicular microlithiasis - testis cancer - prevalence - follow-up