Elastic and ultradeformable liposomes were synthesized and physicochemically characterized
to make suitable topical formulations for delivering the anti-inflammatory and anticancer
compound 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid. The average sizes
of elastic and ultradeformable liposomes are below 300 nm, while the size distribution
and Z-potential are below 0.3 and − 25 mV, respectively. The presence of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic
acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable
liposomes show a zero order release kinetic and are stable at room temperature for
a long time with or without 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid.
The ultradeformable liposomes are more deformable than elastic liposomes. These differences
may depend on sodium cholate derivatives making nanoformulations. The 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic
acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based
natural compounds for the potential treatment of cutanous inflammation.
Key words
Acronychiabaueri species - elastic liposomes - ultradeformable liposomes - ethosomes - transfersomes
- deformability study
