Dtsch Med Wochenschr 2016; 141(18): 1296-1303
DOI: 10.1055/s-0042-110555
Dossier
Schwangere beim Internisten
© Georg Thieme Verlag KG Stuttgart · New York

Diabetes in der Schwangerschaft

Typ-1- / Typ-2-Diabetes mellitus und Gestationsdiabetes mellitusDiabetes in Pregnancy – Type 1/Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus
Helmut Kleinwechter
1   diabetologikum kiel, Diabetes-Schwerpunktpraxis und Schulungszentrum
,
Norbert Demandt
1   diabetologikum kiel, Diabetes-Schwerpunktpraxis und Schulungszentrum
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
06. September 2016 (online)

Zusammenfassung

Bei 5,5% aller Geburten wird in Deutschland ein Diabetes registriert. Für den guten Ausgang einer Schwangerschaft bei Typ-1 und Typ-2 Diabetes sind Planung der Schwangerschaft, präkonzeptionelle Beratung, diabetologische Betreuung mit Optimierung der perikonzeptionellen Stopffwechseleinstellung und Folsäuresupplementierung vorrangig. Beim Gestationsdiabetes (GDM) kommt es auf rechtzeitige und leitliniengerechte Diagnostik und Therapie an. GDM wird in ca. 20% mit Insulin behandelt. In 1-2% der Fälle von GDM liegt eine Glukokinase-Genmutation vor (MODY 2). Schwangerschaften nach bariatrisch-metabolischer Chirurgie nehmen zu und haben hohe Risiken.

Abstract

In Germany in 5.5% of all births diabetes is registered. In patients with type 1 and type 2 diabetes planning pregnancy, preconception counseling, diabetologic care with optimized periconceptional metabolic control and folic acid supplementation are essential for good pregnancy outcome. Gestational diabetes (GDM) should be diagnosed timely and managed according to existing guidelines. GDM is treated with insulin in approximately 20%. In 1-2% of GDM cases a glucokinase gene mutation is present (MODY 2). Pregnancies after bariatric-metabolic surgery are increasing and show high risks.

 
  • Literatur

  • 1 AQUA. 16 / 1 – Geburtshilfe, Qualitätsindikatoren. 2015 www.sqg.de/downloads/Bundesauswertungen/2014/bu_Gesamt_16N1-GEBH_2014.pdf letzter Zugriff: 23.12.2015
  • 2 Tamayo T, Rathmann W. Epidemiologie des Diabetes in Deutschland. In: Deutscher Gesundheitsbericht Diabetes 2016: 9–17 www.diabetesde.org/fileadmin/users/Patientenseite/PDFs_und_TEXTE/Infomaterial/Gesundheitsbericht_2016.pdf letzter Zugriff: 29.06.2016
  • 3 Coton S, Nazareth I, Petersen I. A cohort study of trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice between 1995 and 2012. BMJ Open 2016; 6: e009494
  • 4 Kerner W, Brückel J. Definition, Klassifikation und Diagnostik des Diabetes mellitus. Diabetologie 2015; 10: S98-S101
  • 5 Kleinwechter H, Bührer C, Hunger-Battefeld W et al. S3-Leitlinie Diabetes und Schwangerschaft. Evidenzbasierte Leitlinie der Deutschen Diabetes-Gesellschaft. www.deutsche-diabetes-gesellschaft.de/fileadmin/Redakteur/Leitlinien/Evidenzbasierte_Leitlinien/Eb_Leitlinie_DS_16-12-14_UEberarbeitung_Endfassung.pdf letzter Zugriff: 22.05.2016
  • 6 Kleinwechter H, Schäfer-Graf U, Bührer C et al. Gestationsdiabetes mellitus (GDM). Evidenzbasierte Leitlinie zu Diagnostik, Therapie u. Nachsorge der Deutschen Diabetes-Gesellschaft und der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Diabetologie 2011; 6: 290-328
  • 7 Kleinwechter H, Demandt N. Präkonzeptionelle Beratung diabetischer Frauen, Aktueller Stand. Diabetologe 2016; 12: 32-39
  • 8 Balsells M, García-Patterson A, Gich I et al. Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis. J Clin Endocrinol Metab 2009; 94: 4284-4291
  • 9 Kleinwechter H, Schäfer-Graf U. Diabetes, pregnancy and the kidney. In: Wolf G, Hrsg. Diabetes and Kidney Disease. Chichester: Wiley; 2013: 129-142
  • 10 Nielsen R, Müller C, Damm P et al. Reduced prevalence of early delivery in women with type 1 diabetes and microalbuminuria – possible effect of early antihypertensive treatment during pregnancy. Diabet Med 2006; 23: 426-431
  • 11 Ringholm Nielsen L, Pedersen-Bjergaard U, Thorsteinsson B et al. Hypoglycemia in pregnant women with type 1 diabetes. Predictors and role of metabolic control. Diabetes Care 2008; 31: 9-14
  • 12 Bullo M, Tschumi S, Bucher B et al. Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists. A systematic review. Hypertension 2012; 60: 444-450
  • 13 Edison R, Muenke M. Central nervous system and limb anomalies in case reports of first-trimester statin exposure. N Engl J Med 2004; 350: 1579-1582
  • 14 Mathiesen E, Hod M, Ivanesivic M et al. Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes. Diabetes Care 2012; 35: 2012-2017
  • 15 Mathiesen E, Kinsley B, Amiel S et al. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy. A randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 2007; 30: 771-776
  • 16 Hod M, Damm P, Kaaja R et al. Fetal and perinatal outcomes in type 1 diabetes pregnancy: a randomized study comparing insulin aspart with human insulin in 322 subjects. Am J Obstet Gynecol 2008; 198: 186.e1-7
  • 17 Hod M, Mathiesen E, Jovanovic L et al. A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamin Hagedorn in Type 1 Diabetes. J Matern Fetal Neontal Med 2014; 27: 7-13
  • 18 Herrera K, Rosenn B, Fourutan J et al. Randomized controlled trial of insulin detemir versus NPH for the treatment of pregnant women with diabetes. Am J Obstet Gynecol 2015; 213: 426.e1-426.e7
  • 19 Blanco C, Ballesteros A, Saladich I et al. Glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus using lispro versus regular insulin: a systematic review and meta-analysis. Diabetes Technol Ther 2011; 13: 907-911
  • 20 Mukhopadhyay A, Farrell T, Fraser R et al. Continous subcutaneous insulin infusion vs. intensive conventional insulin therapy in pregnant diabetic women: a systematic review and metaanalysis of randomized, controlled trials. Am J Obstet Gynecol 2007; 197: 447-456
  • 21 Murphy H, Lewis RaymanG et al. Effectiveness of continuous glucose monitoring in pregnant women with diabetes: a randomized clinical trial. BMJ 2008; 337: a1680
  • 22 Hewapathirana N, O’Sullivan E, Murphy H. Role of continuous glucose monitoring in the management of diabetic pregnancy. Curr Diab Rep 2013; 13: 34-42
  • 23 Secher A, Ringholm L, Andersen H et al. The effect of real-time continuous glucose monitoring in pregnant women with diabetes. A randomized controlled trial. Diabetes Care 2013; 36: 1877-1883
  • 24 Murphy H. Continuous glucose monitoring in pregnancy: we have the technology but not all the answers. Diabetes Care 2013; 36: 1818-1819
  • 25 Cordua S, Secher A, Ringholm L et al. Real-time glucose monitoring during labour and delivery in women with type 1 diabetes – observations from a randomized controlled trial. Diabet Med 2013; 30: 1374-1383
  • 26 Secher A, Stage E, Ringholm L et al. Real-time continuous glucose monitoring as a tool to prevent severe hypoglycemia in selected pregnant women with type 1 diabetes – an observational study. Diabet Med 2014; 31: 352-356
  • 27 Shimizu I, Makino H, Imagawa A et al. Clinical and immunogenetic characteristics of fulminant type 1 diabetes associated with pregnancy. J Clin Endocrin Metabol 2006; 91: 471-476
  • 28 Hummel M. Typ-1b-Diabetes – Neumanifestation in der Schwangerschaft. Vortrag auf der 51. Jahrestagung der DDG in Berlin am 06.05.2016
  • 29 Johansson K, Cnattingius S, Näslund I et al. Outcomes of pregnancy after bariatric surgery. N Engl J Med 2015; 372: 814-824
  • 30 Caughey A. bariatric surgery before pregnancy – is this a solution to a big problem?. N Engl J Med 2015; 372: 877-888
  • 31 World Health Organization. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. WHO Press; Genf: 2013. apps.who.int/iris/bitstream/10665/85975/1/WHO_NMH_MND_13.2_eng.pdf letzter Zugriff: 29.06.2016
  • 32 Catalano P. Trying to understand gestational diabetes. Diabet Med 2014; 31: 273-281
  • 33 The HAPO Study Cooperative Research Group: Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008; 358: 1991-2002
  • 34 Nehring I, Chmitorz A, Reulen H et al. Gestational diabetes predicts the risk of childhood overweight and abdominal circumference independent of maternal obesitiy. Diabet Med 2013; 30: 1449-1456
  • 35 International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010; 33: 676-682
  • 36 Kleinwechter H, Schäfer-Graf U, Bührer C et al. Gestationsdiabetes mellitus (GDM) – Diagnostik, Therapie und Nachsorge. Diabetologie 2015; 10 (Suppl 2) S205-S217
  • 37 Kleinwechter H, Heinemann L, Freckmann G. Diagnostik des Gestationsdiabetes: Die Crux liegt bei der Blutentnahme. Perspektiven der Diabetologie 1 / 2015. Dtsch Arzteblatt 2015; 24-27
  • 38 Van den Berg S, Thelen M, Salden L et al. It takes acid, rather than ice, to freeze glucose. Sci Rep 2015; 5: 8875
  • 39 Bonomo M, Cetin I, Pisoni M et al. Flexible treatment of gestational diabetes modulated on ultrasound evaluation of intrauterine growth: a controlled randomized clinical trial. Diabetes Metab 2004; 30: 237-244
  • 40 Schaefer-Graf U, Kjos S, Fauzan O et al. A randomized trial evaluating a predominately fetal-growth-based strategy to guide management of gestational diabetes in Caucasian women. Diabetes Care 2004; 27: 297-302
  • 41 Crowther C, Hiller E, Moss J et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005; 352: 2477-2486
  • 42 Landon M, Spong C, Thom E et al for the Eunice Kennedy Shriver Nationale Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Network. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med 2009; 361: 1339-1348
  • 43 Balaji V, Balaji M, Alexander C et al. Premixed insulin aspart 30 (BIAsp 30) versus premixed human insulin 30 (BHI 30) in gestational diabetes mellitus: a randomized open-label controlled study. Gynecol Endocrinol 2012; 28: 529-532
  • 44 Balsells M, Garcia-Patterson A, Solà I et al. Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. BMJ 2015; 350: h102
  • 45 Camello C, Boggess K, Sturmer T et al. Trends in glyburide compared with insulin use for gestational diabetes treatment in the Unites States, 2000–2011. Obstet Gynecol 2014; 123: 1177-1184
  • 46 Holt R, Lambert K. Review Article. The use of oral hypoglycaemic agents in pregnancy. Diabet Med 2014; 31: 282-291
  • 47 Bellamy L, Casa J, Hingorani A et al. Type 2 Diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009; 373: 1773-1779
  • 48 Gunderson E, Huston S, Ning X et al. for the Study of Women Feeding and Type 2 Diabetes After GDM Pregnancy Investigators. Lactation and progression to type 2 diabetes mellitus after gestational diabetes mellitus: a prospective cohort study. Ann Intern Med 2015; 163: 889-898
  • 49 Ratner R, Christophi C, Metzger B et al. The Diabetes Prevention Program Research Group. Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. J Clin Endocrin Metabol 2008; 93: 4774-4779
  • 50 Aroda V, Christophi C, Edelstein S et al. for the Diabetes Prevention Program Research Group. The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes prevention program outcomes study 10-year follow-up. J Clin Endocrinol Metab 2015; 100: 1646-1653
  • 51 Bacon S, Schmid J, McCarthy A et al. The clinical management of hyperglycemia in pregnancy complicated by maturity-onset diabetes of the young. Am J Obstet Gynecol 2015; 213: 236.e1-e7
  • 52 Bundesministerium der Justiz und für Verbraucherschutz. Gesetz über genetische Untersuchungen bei Menschen (Gendiagnostikgesetz – GenDG). www.gesetze-im-internet.de/bundesrecht/gendg/gesamt.pdf letzter Zugriff: 22.05.2016
  • 53 Rudland V, Hinchcliffe M, Pinner J et al. Identifying glucokinase monogenic diabetes in a multiethnic gestational diabetes cohort: new pregnancy screening criteria and utility of HbA1c . Diabetes Care 2016; 39: 50-52
  • 54 Chakera A, Spyer G Vicent et al. The 0.1 % of the population with glucokinase monogentic diabetes can be recognized by clinical characteristics in pregnancy: the atlantic diabetes in pregnancy cohort. Diabetes Care 2014; 37: 1230-1236
  • 55 Hattersley A, Beards F, Ballantyne E et al. Mutations in the glucokinase gene of the fetus results in reduced birth weight. Nat Genet 1998; 19: 268-270
  • 56 Stride A, Shepherd M, Frayling T et al. Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1α gene mutation carriers. Diabetes Care 2002; 25: 2287-2291
  • 57 www.embryotox.de Informationen zu Medikamenten. www.embryotox.de/wirkstoffe-auswahl.html letzter Zugriff: 21.05.2016