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Drug Res (Stuttg) 2016; 66(10): 506-519
DOI: 10.1055/s-0042-109865
Review
© Georg Thieme Verlag KG Stuttgart · New York

Applications of Copolymeric Nanoparticles in Drug Delivery Systems

H. Danafar
1   Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2   Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
› Author Affiliations
Further Information

Publication History

received 14 April 2016

accepted 24 May 2016

Publication Date:
12 July 2016 (online)

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Abstract

Nanoparticles have outstanding compensate compared with other drug carriers, as a result of their small particle size and bulky and changeable surface. Recently, block copolymers have get imaginary movement on the continuing research in the area of drug delivery technology, because of their potential to afford a biomaterial having an extensive series of amphiphilic personality, in addition to targeting the drugs to specific position. Block copolymers are prepared up of blocks of different polymerized monomers. Between the block copolymers, amphiphilic block copolymers can self-assemble to form nano-sized vehicles, for example micelles, liposomes, polymerases and hydrogels in aqueous or non-aqueous media. This review evaluated the synthesis, construction, and major applications of amphiphilic block copolymer and analogous vehicles in order to provide an overview of the present features of functionalized block copolymers for drug delivery applications.

Key words

block copolymer - drug delivery system - hydrogels - micelles - nanoparticles
 

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