Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum

Abstract

Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine (3) and N-[7′-(4′-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6–15) showed antifungal activity against Cryptococcus neoformans ATCC 90 113 with IC₅₀ values in the range between 4.7 and 20.0 µg/mL.

Key words

Piper flaviflorum - Piper sarmentosum - Piperaceae - amide alkaloids - antifungal activity

^* These authors contributed equally to this work.

• References

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