Background and study aims: Endoscopic retrograde pancreatocholangiography (ERCP) is associated with many types
of adverse events (AEs) but idiopathic perforation of the gallbladder (IPGB) is very
rare. Pancreatobiliary reflux is one of the factors involved with occurrence of IPGB
[1]. Here we present a case of acalculous gallbladder perforation as an AE following
the insertion of an indwelling endoscopic nasal pancreatic drainage (ENPD) tube (a
pancreatic stent) to obtain pancreatic fluid. In this case, acute pancreatobiliary
reflux might have been caused by the insertion of the ENPD-tube.