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Drug Res (Stuttg) 2016; 66(08): 444-448
DOI: 10.1055/s-0042-109394
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

A. Khonche
1   Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
O. Biglarian
1   Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
Y. Panahi
2   Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
G. Valizadegan
1   Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
S. S. Soflaei
3   Neurogenic Inflammation Research Center, Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Iran
,
M. E. Ghamarchehreh
1   Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
,
M. Majeed
4   Sabinsa Inc, Princeton, NJ, United States
,
A. Sahebkar
5   Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6   Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
› Author Affiliations
Further Information

Publication History

received 03 May 2016

accepted 27 May 2016

Publication Date:
28 June 2016 (online)

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Abstract

Background: Curcumin, the bioactive ingredient of turmeric, has been shown to improve the treatment of peptic ulcer (PU) in animal studies. However, clinical studies confirming this effect of curcumin have been scant.

Objective: To assess the efficacy of adjunctive therapy with curcumin on the eradication of Helicobacter pylori infection and severity of dyspepsia in patients with PU.

Methods: In this randomized double-blind placebo-controlled parallel-group trial, patients diagnosed with PU were assigned to standard H. pylori eradication triple therapy with clarithromycin (500 mg b.i.d.), amoxicillin (1 000 mg b.i.d.) and pantoprazole (40 mg b.i.d.), and randomized to receive either curcumin (500 mg/day) or placebo as adjunct to standard treatment. Severity of dyspepsia symptoms was evaluated using the Hong Kong dyspepsia index (HKDI). Eradication of H. pylori infection was assessed using the urea breath test (UBT) at 4 weeks following the end of treatment.

Results: Adjunctive therapy with curcumin was associated with a greater improvement of dyspepsia symptoms according to the HKDI score (change score: −12.90±2.81 vs. −9.60±3.39 in the curcumin and control group, respectively; p<0.001). The number of subjects whose dyspepsia was resolved during the course of treatment was significantly higher in the curcumin (27.6%) vs. placebo (6.7%) group (p=0.042). Nevertheless, the results of UBT test showed equal rate (73.3%) of H. pylori eradication in the study groups. Curcumin was safe during the course of trial.

Conclusion: Addition of curcumin on top of the standard anti-helicobacter regimen in patients with PU is safe and improves dyspepsia symptoms but has no enhancing effect on the eradication of H. pylori infection.

Key words

peptic ulcer - dyspepsia - helicobacter pylori - curcumin - randomized controlled trial
 

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