Planta Med 2016; 82(11/12): 1079-1086
DOI: 10.1055/s-0042-108857
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert[*]

Beth Ndunda
1  Department of Chemistry, University of Nairobi, Nairobi, Kenya
2  Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom
,
Moses K. Langat
2  Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom
3  School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
,
Dulcie A. Mulholland
2  Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom
3  School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
,
Harry Eastman
2  Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom
,
Melissa R. Jacob
4  National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA
,
Shabana I. Khan
4  National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA
5  Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, MS, USA
,
Larry A. Walker
4  National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA
5  Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, MS, USA
,
Ilias Muhammad
4  National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA
,
Leonidah O. Kerubo
1  Department of Chemistry, University of Nairobi, Nairobi, Kenya
,
Jacob O. Midiwo
1  Department of Chemistry, University of Nairobi, Nairobi, Kenya
› Author Affiliations
Further Information

Publication History

received 03 March 2016
revised 09 May 2016

accepted 10 May 2016

Publication Date:
10 June 2016 (eFirst)

Abstract

The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated. Among them were twelve new ent-clerodane (112) and a new abietane (13) diterpenoids, alongside the known crotocorylifuran (4 a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds were evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.

* Dedicated to Professor Dr. Dr. h. c. mult. Kurt Hostettmann in recognition of his outstanding contribution to natural product research.


Supporting Information