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Planta Medica International Open 2016; 3(02): e39-e42
DOI: 10.1055/s-0042-108808
Letter
Georg Thieme Verlag KG Stuttgart · New York

Lipopolysaccharide-Induced Nitric Oxide and Prolyl Oligopeptidase – Inhibitory Activities of Triterpenoids from Sanguisorba officinalis

Hongyu Ma
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Peopleʼs Republic of China
,
Xizhe Li
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Peopleʼs Republic of China
,
Yuchen Zhang
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Peopleʼs Republic of China
,
Guangsong Chu
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Peopleʼs Republic of China
,
Zhong Yuan
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 22 September 2015
revised 02 March 2016

accepted 13 May 2016

Publication Date:
15 August 2016 (online)

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Abstract

Lipopolysaccharide-induced nitric oxide and the protease prolyl oligopeptidase (EC 3.4.21.26) have been proposed as targets for the treatment of cognitive disturbances such as dementia. In this study, nine triterpenoids isolated from the roots of Sanguisorba officinalis, including arjunic acid (1), rosamultic acid (2), haptadienic acid (3), 1β-hydroxyeuscaphic acid (4), euscaphic acid (5), tormentic acid (6), pomolic acid (7), ursolic acid (8), and oleanolic acid (9), were tested in vitro for their inhibitory activities on lipopolysaccharide-induced nitric oxide in N9 microglia cells and on prolyl oligopeptidase. Among them, 7 exhibited the strongest inhibitory activity on lipopolysaccharide-induced nitric oxide (IC50, 21.9 µM), while 8 and 9 exhibited a significant prolyl oligopeptidase inhibitory activity (IC50 18.1 and 24.0 µM, respectively). The results could provide a clue that these triterpenoids are responsible for the reported neuro-protective effect of S. officinalis.

Key words

Sanguisorba officinalis - Rosaceae - triterpenoids - lipopolysaccharide-induced nitric oxide - prolyl oligopeptidase
 

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