Planta Med 2016; 82(11/12): 1128-1133
DOI: 10.1055/s-0042-108736
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

ent-Eudesmane-Type Sesquiterpenoids from the Chinese Liverwort Chiloscyphus polyanthus var. rivularis [*]

Jiao-Zhen Zhang
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Ya-Nan Qiao
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Lin Li
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Yong-Jie Wang
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Yi Li
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Xie Fei
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Jin-Chuan Zhou
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Xiao Wang
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Pei-Hong Fan
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
,
Hong-Xiang Lou
Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 22 February 2016
revised 03 May 2016

accepted 03 May 2016

Publication Date:
23 June 2016 (eFirst)

Abstract

Seven new ent-eudesmane-type sesquiterpenoids (17) and six known analogues (813) were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were determined from analysis of MS and NMR spectroscopic data and single-crystal X-ray diffraction. A cytotoxic evaluation showed that compound 1 exhibited weak inhibitory activity against the A549 cancer cell line with an IC50 value of 27.7 µM.

* Dedicated to Professor Dr. Dr. h. c. mult. Kurt Hostettmann recognition of his outstanding contribution to natural product research.


Supporting Information