Planta Med 2016; 82(11/12): 961-966
DOI: 10.1055/s-0042-108205
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Biological Activity of Polynesian Calophyllum inophyllum Oil Extract on Human Skin Cells[*]

Jean-Luc Ansel
1  Université de la Polynésie Française, Faaʼa, Tahiti, Polynésie Française
,
Elise Lupo
2  Centre de Biophysique Moléculaire, Orléans, France
,
Lily Mijouin
2  Centre de Biophysique Moléculaire, Orléans, France
6  Remedials Laboratoire, Paris, France
,
Samuel Guillot
3  Interfaces, Confinement, Matériaux et Nanostructures (ICMN), Université dʼOrléans, CNRS, UMR 7374, Orléans, France
,
Jean-François Butaud
4  Consultant en foresterie et botanique polynésienne, Pirae, Tahiti, Polynésie Française
,
Raimana Ho
1  Université de la Polynésie Française, Faaʼa, Tahiti, Polynésie Française
,
Gaël Lecellier
5  Université de Versailles Saint-Quentin en Yvelines, Versailles, France
,
Phila Raharivelomanana**
1  Université de la Polynésie Française, Faaʼa, Tahiti, Polynésie Française
,
Chantal Pichon**
2  Centre de Biophysique Moléculaire, Orléans, France
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 23. Februar 2016
revised 18. April 2016

accepted 22. April 2016

Publikationsdatum:
09. Juni 2016 (eFirst)

Abstract

Oil from the nuts of Calophyllum inophyllum, locally called “Tamanu oil” in French Polynesia, was traditionally used for wound healing and to cure various skin problems and ailments. The skin-active effect of “Tamanu oil emulsion” was investigated on human skin cells (keratinocytes and dermal fibroblasts) and showed cell proliferation, glycosaminoglycan and collagen production, and wound healing activity. Transcriptomic analysis of the treated cells revealed gene expression modulation including genes involved in the metabolic process implied in O-glycan biosynthesis, cell adhesion, and cell proliferation. The presence of neoflavonoids as bioactive constituents in Tamanu oil emulsion may contribute to these biological activities. Altogether, consistent data related to targeted histological and cellular functions brought new highlights on the mechanisms involved in these biological processes induced by Tamanu oil effects in skin cells.

* Dedicated to Professor Dr. Dr. h. c. mult. Kurt Hostettmann in recognition of his outstanding contribution to natural product research.


** Phila Raharivelomanana and Chantal Pichon have an equal contribution as co-last authors in this work.


Supporting Information