Planta Med 2017; 83(01/02): 126-134
DOI: 10.1055/s-0042-108057
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities

Xu Pang*
1  Beijing Institute of Radiation Medicine, Beijing, China
2  Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
,
Li-Ping Kang*
1  Beijing Institute of Radiation Medicine, Beijing, China
3  Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Xiao Mei Fang*
2  Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
,
Yang Zhao
1  Beijing Institute of Radiation Medicine, Beijing, China
,
He-Shui Yu
3  Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Li-Feng Han
3  Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Hai-Tao Li
4  Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong, China
,
Li-Xia Zhang
4  Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong, China
,
Bao-Lin Guo
5  Institute of Medicinal Plant development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
,
Li-Yan Yu
2  Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
,
Bai-Ping Ma
1  Beijing Institute of Radiation Medicine, Beijing, China
› Author Affiliations
Further Information

Publication History

received 14 July 2015
revised 17 April 2016

accepted 19 April 2016

Publication Date:
07 June 2016 (online)

Abstract

A continuous phytochemical study on the roots of Marsdenia tenacissima led to the isolation and identification of 13 new polyoxypregnane glycosides named marstenacissides B10–B17 (1, 2, 4, 7, 8, 11, 12, and 14) and marstenacissides A8-A12 (3, 9, 10, 13, and 15) in addition to two known polyoxypregnane glycosides marsdenosides M and L (5 and 6). Their structures were established by spectroscopic techniques and by comparison with the reported data in the literature. Moreover, the anti-HIV activities of these isolates and the previous isolated marstenacissides A1–A7 and B1–B9 were assessed, some of which exhibited slight or negligible effects against HIV-1.

* These authors contributed equally to this work.


Supporting Information